Your browser doesn't support javascript.
loading
Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet-A Randomized Controlled Trial in Healthy Participants.
Lederer, Ann-Kathrin; Hannibal, Luciana; Hettich, Manuel; Behringer, Sidney; Spiekerkoetter, Ute; Steinborn, Carmen; Gründemann, Carsten; Zimmermann-Klemd, Amy Marisa; Müller, Alexander; Simmet, Thomas; Schmiech, Michael; Maul-Pavicic, Andrea; Samstag, Yvonne; Huber, Roman.
Afiliación
  • Lederer AK; Center for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Hannibal L; Laboratory of Clinical Biochemistry and Metabolism, Department of General Pediatrics, Medical Center-University of Freiburg, Adolescent Medicine and Neonatology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Hettich M; Center for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Behringer S; Laboratory of Clinical Biochemistry and Metabolism, Department of General Pediatrics, Medical Center-University of Freiburg, Adolescent Medicine and Neonatology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Spiekerkoetter U; Laboratory of Clinical Biochemistry and Metabolism, Department of General Pediatrics, Medical Center-University of Freiburg, Adolescent Medicine and Neonatology, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Steinborn C; Center for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Gründemann C; Center for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Zimmermann-Klemd AM; Center for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Müller A; Center for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Simmet T; Institute of Pharmacology of Natural Products & Clinical Pharmacology, Ulm University, 89081 Ulm, Germany.
  • Schmiech M; Institute of Pharmacology of Natural Products & Clinical Pharmacology, Ulm University, 89081 Ulm, Germany.
  • Maul-Pavicic A; Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Samstag Y; Center of Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
  • Huber R; Institute of Immunology, Section Molecular Immunology, University of Heidelberg, 69120 Heidelberg, Germany.
Nutrients ; 11(11)2019 Nov 18.
Article en En | MEDLINE | ID: mdl-31752105
Vegans are at an increased risk for certain micronutrient deficiencies, foremost of vitamin B12. Little is known about the short-term effects of dietary change to plant-based nutrition on vitamin B12 metabolism. Systemic biomarkers of vitamin B12 status, namely, serum vitamin B12 and holotranscobalamin, may respond quickly to a reduced intake of vitamin B12. To test this hypothesis, 53 healthy omnivore subjects were randomized to a controlled unsupplemented vegan diet (VD, n = 26) or meat-rich diet (MD, n = 27) for 4 weeks. Vitamin B12 status was examined by measurement of serum vitamin B12, holotranscobalamin (holo-TC), methylmalonic acid (MMA) and total plasma homocysteine (tHcy). Holo-TC decreased significantly in the VD compared to the MD group after four weeks of intervention, whereas metabolites MMA and tHcy were unaffected. Body weight remained stable in both groups. VD intervention led to a significant reduction of cholesterol intake, and adequate profiles of nutrient and micronutrient status. Lower intake of vitamin B12 was observed in VD, which was mirrored by a lower concentration of serum vitamin B12 and reduced holo-TC after 4 weeks. Plasma holo-TC may be a fast-responding biomarker to monitor adequate supply of vitamin B12 in plant-based individuals.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina B 12 / Biomarcadores / Estado Nutricional / Dieta Vegana Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male Idioma: En Revista: Nutrients Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina B 12 / Biomarcadores / Estado Nutricional / Dieta Vegana Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male Idioma: En Revista: Nutrients Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza