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Stabilization of Long-Looped i-Motif DNA by Polypyridyl Ruthenium Complexes.
Pages, Benjamin J; Gurung, Sarah P; McQuaid, Kane; Hall, James P; Cardin, Christine J; Brazier, John A.
Afiliación
  • Pages BJ; School of Pharmacy, University of Reading, Reading, United Kingdom.
  • Gurung SP; Department of Chemistry, University of Reading, Reading, United Kingdom.
  • McQuaid K; Diamond Light Source, Didcot, United Kingdom.
  • Hall JP; Department of Chemistry, University of Reading, Reading, United Kingdom.
  • Cardin CJ; Diamond Light Source, Didcot, United Kingdom.
  • Brazier JA; School of Pharmacy, University of Reading, Reading, United Kingdom.
Front Chem ; 7: 744, 2019.
Article en En | MEDLINE | ID: mdl-31750292
A spectroscopic study of the interactions of Λ- and Δ-[Ru(phen)2(dppz)]2+ with i-motif DNA containing thymine loops of various lengths. In the presence of i-motifs, the luminescence of the Λ enantiomer was enhanced much more than the Δ. Despite this, the effect of each enantiomer on i-motif thermal stability was comparable. The sequences most affected by [Ru(phen)2(dppz)]2+ were those with long thymine loops; this suggests that long-looped i-motifs are attractive targets for potential transition metal complex drugs and should be explored further in drug design.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Chem Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Chem Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Suiza