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Circular ecDNA promotes accessible chromatin and high oncogene expression.
Wu, Sihan; Turner, Kristen M; Nguyen, Nam; Raviram, Ramya; Erb, Marcella; Santini, Jennifer; Luebeck, Jens; Rajkumar, Utkrisht; Diao, Yarui; Li, Bin; Zhang, Wenjing; Jameson, Nathan; Corces, M Ryan; Granja, Jeffrey M; Chen, Xingqi; Coruh, Ceyda; Abnousi, Armen; Houston, Jack; Ye, Zhen; Hu, Rong; Yu, Miao; Kim, Hoon; Law, Julie A; Verhaak, Roel G W; Hu, Ming; Furnari, Frank B; Chang, Howard Y; Ren, Bing; Bafna, Vineet; Mischel, Paul S.
Afiliación
  • Wu S; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
  • Turner KM; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
  • Nguyen N; Boundless Bio, Inc., La Jolla, CA, USA.
  • Raviram R; Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA.
  • Erb M; Boundless Bio, Inc., La Jolla, CA, USA.
  • Santini J; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
  • Luebeck J; UCSD Light Microscopy Core Facility, Department of Neurosciences, University of California at San Diego, La Jolla, CA, USA.
  • Rajkumar U; UCSD Light Microscopy Core Facility, Department of Neurosciences, University of California at San Diego, La Jolla, CA, USA.
  • Diao Y; Bioinformatics & Systems Biology Graduate Program, University of California at San Diego, La Jolla, CA, USA.
  • Li B; Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA.
  • Zhang W; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
  • Jameson N; Department of Cell Biology, Regeneration Next Initiative, Duke University School of Medicine, Durham, NC, USA.
  • Corces MR; Department of Orthopaedic Surgery, Regeneration Next Initiative, Duke University School of Medicine, Durham, NC, USA.
  • Granja JM; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
  • Chen X; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
  • Coruh C; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
  • Abnousi A; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.
  • Houston J; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.
  • Ye Z; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.
  • Hu R; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Yu M; Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
  • Kim H; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
  • Law JA; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
  • Verhaak RGW; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
  • Hu M; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
  • Furnari FB; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
  • Chang HY; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
  • Ren B; Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
  • Bafna V; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
  • Mischel PS; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Nature ; 575(7784): 699-703, 2019 11.
Article en En | MEDLINE | ID: mdl-31748743
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oncogenes / ADN Circular / Cromatina / Regulación Neoplásica de la Expresión Génica / Neoplasias Límite: Humans Idioma: En Revista: Nature Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oncogenes / ADN Circular / Cromatina / Regulación Neoplásica de la Expresión Génica / Neoplasias Límite: Humans Idioma: En Revista: Nature Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido