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Manipulations of Central Amygdala Neurotensin Neurons Alter the Consumption of Ethanol and Sweet Fluids in Mice.
Torruella-Suárez, María Luisa; Vandenberg, Jessica R; Cogan, Elizabeth S; Tipton, Gregory J; Teklezghi, Adonay; Dange, Kedar; Patel, Gunjan K; McHenry, Jenna A; Hardaway, J Andrew; Kantak, Pranish A; Crowley, Nicole A; DiBerto, Jeffrey F; Faccidomo, Sara P; Hodge, Clyde W; Stuber, Garret D; McElligott, Zoé A.
Afiliación
  • Torruella-Suárez ML; Neuroscience Curriculum.
  • Vandenberg JR; Bowles Center for Alcohol Studies.
  • Cogan ES; Bowles Center for Alcohol Studies.
  • Tipton GJ; Bowles Center for Alcohol Studies.
  • Teklezghi A; Bowles Center for Alcohol Studies.
  • Dange K; Bowles Center for Alcohol Studies.
  • Patel GK; Bowles Center for Alcohol Studies.
  • McHenry JA; Bowles Center for Alcohol Studies.
  • Hardaway JA; Department of Psychiatry.
  • Kantak PA; Neuroscience Center, and.
  • Crowley NA; Bowles Center for Alcohol Studies.
  • DiBerto JF; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599.
  • Faccidomo SP; Department of Psychiatry.
  • Hodge CW; Neuroscience Curriculum.
  • Stuber GD; Bowles Center for Alcohol Studies.
  • McElligott ZA; Bowles Center for Alcohol Studies.
J Neurosci ; 40(3): 632-647, 2020 01 15.
Article en En | MEDLINE | ID: mdl-31744862
The central nucleus of the amygdala plays a significant role in alcohol use and other affective disorders; however, the genetically-defined neuronal subtypes and projections that govern these behaviors are not well known. Here we show that neurotensin neurons in the central nucleus of the amygdala of male mice are activated by in vivo ethanol consumption and that genetic ablation of these neurons decreases ethanol consumption and preference in non-ethanol-dependent animals. This ablation did not impact preference for sucrose, saccharin, or quinine. We found that the most robust projection of the central amygdala neurotensin neurons was to the parabrachial nucleus, a brain region known to be important in feeding behaviors, conditioned taste aversion, and alarm. Optogenetic stimulation of projections from these neurons to the parabrachial nucleus is reinforcing, and increases ethanol drinking as well as consumption of sucrose and saccharin solutions. These data suggest that this central amygdala to parabrachial nucleus projection influences the expression of reward-related phenotypes and is a novel circuit promoting consumption of ethanol and palatable fluids.SIGNIFICANCE STATEMENT Alcohol use disorder (AUD) is a major health burden worldwide. Although ethanol consumption is required for the development of AUD, much remains unknown regarding the underlying neural circuits that govern initial ethanol intake. Here we show that ablation of a population of neurotensin-expressing neurons in the central amygdala decreases intake of and preference for ethanol in non-dependent animals, whereas the projection of these neurons to the parabrachial nucleus promotes consumption of ethanol as well as other palatable fluids.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Consumo de Bebidas Alcohólicas / Neurotensina / Núcleo Amigdalino Central / Preferencias Alimentarias / Neuronas Límite: Animals Idioma: En Revista: J Neurosci Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Consumo de Bebidas Alcohólicas / Neurotensina / Núcleo Amigdalino Central / Preferencias Alimentarias / Neuronas Límite: Animals Idioma: En Revista: J Neurosci Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos