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Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues.
Sanchez Bosch, Pablo; Makhijani, Kalpana; Herboso, Leire; Gold, Katrina S; Baginsky, Rowan; Woodcock, Katie J; Alexander, Brandy; Kukar, Katelyn; Corcoran, Sean; Jacobs, Thea; Ouyang, Debra; Wong, Corinna; Ramond, Elodie J V; Rhiner, Christa; Moreno, Eduardo; Lemaitre, Bruno; Geissmann, Frederic; Brückner, Katja.
Afiliación
  • Sanchez Bosch P; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
  • Makhijani K; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
  • Herboso L; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
  • Gold KS; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
  • Baginsky R; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
  • Woodcock KJ; King's College London, London, UK.
  • Alexander B; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
  • Kukar K; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
  • Corcoran S; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
  • Jacobs T; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
  • Ouyang D; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
  • Wong C; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
  • Ramond EJV; EPFL, Lausanne, Switzerland.
  • Rhiner C; Champalimaud Center for the Unknown, Lisbon, Portugal.
  • Moreno E; Champalimaud Center for the Unknown, Lisbon, Portugal.
  • Lemaitre B; EPFL, Lausanne, Switzerland.
  • Geissmann F; King's College London, London, UK; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Brückner K; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA; Cardiovascular Research Institute, University of Calif
Dev Cell ; 51(6): 787-803.e5, 2019 12 16.
Article en En | MEDLINE | ID: mdl-31735669
The use of adult Drosophila melanogaster as a model for hematopoiesis or organismal immunity has been debated. Addressing this question, we identify an extensive reservoir of blood cells (hemocytes) at the respiratory epithelia (tracheal air sacs) of the thorax and head. Lineage tracing and functional analyses demonstrate that the majority of adult hemocytes are phagocytic macrophages (plasmatocytes) from the embryonic lineage that parallels vertebrate tissue macrophages. Surprisingly, we find no sign of adult hemocyte expansion. Instead, hemocytes play a role in relaying an innate immune response to the blood cell reservoir: through Imd signaling and the Jak/Stat pathway ligand Upd3, hemocytes act as sentinels of bacterial infection, inducing expression of the antimicrobial peptide Drosocin in respiratory epithelia and colocalizing fat body domains. Drosocin expression in turn promotes animal survival after infection. Our work identifies a multi-signal relay of organismal humoral immunity, establishing adult Drosophila as model for inter-organ immunity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Sanguíneas / Mucosa Respiratoria / Hematopoyesis / Macrófagos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Sanguíneas / Mucosa Respiratoria / Hematopoyesis / Macrófagos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos