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Low concentrations of the benzodiazepine drug oxazepam induce anxiolytic effects in wild-caught but not in laboratory zebrafish.
Vossen, Laura E; Cervený, Daniel; Sen Sarma, Oly; Thörnqvist, Per-Ove; Jutfelt, Fredrik; Fick, Jerker; Brodin, Tomas; Winberg, Svante.
Afiliación
  • Vossen LE; Department of Neuroscience, Uppsala University, Uppsala, Sweden. Electronic address: laura.vossen@neuro.uu.se.
  • Cervený D; Swedish University of Agricultural Sciences, Department of Wildlife, Fish and Environmental Studies, Umeå, Sweden; Umeå University, Department of Chemistry, Umeå, Sweden; University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of
  • Sen Sarma O; Department of Neuroscience, Uppsala University, Uppsala, Sweden.
  • Thörnqvist PO; Department of Neuroscience, Uppsala University, Uppsala, Sweden.
  • Jutfelt F; Norwegian University of Science and Technology, Department of Biology, Trondheim, Norway.
  • Fick J; University of South Bohemia in Ceske Budejovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátisí 728/II, 389 25 Vodnany, Czech Republic.
  • Brodin T; Swedish University of Agricultural Sciences, Department of Wildlife, Fish and Environmental Studies, Umeå, Sweden.
  • Winberg S; Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Sci Total Environ ; 703: 134701, 2020 Feb 10.
Article en En | MEDLINE | ID: mdl-31734507
Pollution by psychoactive pharmaceuticals has been found to disrupt anti-predator behaviors of wild fish. The challenge is now to identify which of the many psychoactive drugs pose the greatest threat. One strategy is to screen for behavioral effects of selected pharmaceuticals using a single, widely available fish species such as zebrafish. Here, we show that although such high-throughput behavioral screening might facilitate comparisons between pharmaceuticals, the choice of strain is essential. While wild-caught zebrafish exposed to concentrations of the anxiolytic drug oxazepam as low as 0.57 µg L-1 showed a reduction in the response to conspecific alarm pheromone, laboratory strain AB did not respond to the alarm cue, and consequently, the anxiolytic effect of oxazepam could not be measured. Adaptation to the laboratory environment may have rendered laboratory strains unfit for use in some ecotoxicological and pharmacological studies, since the results might not translate to wild fish populations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos