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Descriptive study of naevus involution in a series of 74 patients with atypical naevus syndrome under SIAscopy digital follow-up.
Moreno, S; Maiques, O; Gatius, S; Veà, A; Barrera, J; Barcelo, C; Santacana, M; Soria, X; Matias-Guiu, X; Martí, R M.
Afiliación
  • Moreno S; Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida, Spain.
  • Maiques O; Department of Dermatology, Hospital del Vendrell, Xarxa Sanitària i Social de Santa Tecla, Tarragona, Spain.
  • Gatius S; University of Lleida, IRBLleida, Lleida, Spain.
  • Veà A; Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, London, UK.
  • Barrera J; Department of Pathology and Molecular Genetics, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida, Spain.
  • Barcelo C; Centre of Biomedical Research on Cancer (CIBERONC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
  • Santacana M; Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida, Spain.
  • Soria X; Department of Dermatology, Hospital Comarcal de Móra d'Ebre, Tarragona, Spain.
  • Matias-Guiu X; Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida, Spain.
  • Martí RM; University of Lleida, IRBLleida, Lleida, Spain.
J Eur Acad Dermatol Venereol ; 34(6): 1210-1217, 2020 Jun.
Article en En | MEDLINE | ID: mdl-31732990
BACKGROUND: Characterization of nevi involution could help to understand the biological behaviour of melanocytic neoplasms. OBJECTIVE: To describe the frequency and morphology of naevus involution in a series of patients with atypical naevus syndrome under digital follow-up with a SIAscopy program and, in a small sample of fading nevi, to analyse histopathological features and immunohistochemical biomarkers. METHODS: Seventy-four patients registered from April 2007 to July 2014 in the SIAscopy system of the Department of Dermatology of Hospital Arnau de Vilanova of Lleida, Spain, were reviewed. Fourteen naevus cases with fading features were prospectively excised during follow-up. Eleven already excised naevus controls were randomly selected from our archive. RESULTS: We observed that 81% of patients showed, at least, one involutive naevus and 25% of recorded nevi presented this phenomenon; the mean time of involution was 46.7 months. The predominant structural pattern was reticular (>70%), and the most frequently observed regression structures were vascular (33.8%). Histopathological significant higher intensity of inflammatory infiltrate in controls and higher presence of laminar and compact fibrosis and increase of vessels in cases were demonstrated. Regarding immunohistochemical biomarkers, only higher expression of cytoplasmic activated caspase 3 in controls was significant. CONCLUSIONS: Naevus involution is a common phenomenon in patients with dysplastic naevus syndrome. It is usually a slow process, more frequent in naevus with reticular pattern. SIAscopy regression structures are uncommon, with the exception of vascular ones. Histologically, fading involutive pattern is characterized by scarce inflammatory infiltrate and melanophages, delicate fibrosis and increase of vessels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Síndrome del Nevo Displásico / Melanoma / Nevo Tipo de estudio: Observational_studies / Prognostic_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: J Eur Acad Dermatol Venereol Asunto de la revista: DERMATOLOGIA / DOENCAS SEXUALMENTE TRANSMISSIVEIS Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Síndrome del Nevo Displásico / Melanoma / Nevo Tipo de estudio: Observational_studies / Prognostic_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: J Eur Acad Dermatol Venereol Asunto de la revista: DERMATOLOGIA / DOENCAS SEXUALMENTE TRANSMISSIVEIS Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido