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Resistant starch from green banana (Musa sp.) attenuates non-alcoholic fat liver accumulation and increases short-chain fatty acids production in high-fat diet-induced obesity in mice.
Rosado, Carolyne Pimentel; Rosa, Victor Hugo Cordeiro; Martins, Bruna Cadete; Soares, Aruanna Cajaty; Santos, Izabelle Barcellos; Monteiro, Elisa Bernardes; Moura-Nunes, Nathália; da Costa, Cristiane Aguiar; Mulder, Alessandra da Rocha Pinheiro; Daleprane, Julio Beltrame.
Afiliación
  • Rosado CP; Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Rosa VHC; Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Martins BC; Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Soares AC; Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Santos IB; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Monteiro EB; Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Moura-Nunes N; Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • da Costa CA; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Mulder ADRP; Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Daleprane JB; Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: beltrame@uerj.br.
Int J Biol Macromol ; 145: 1066-1072, 2020 Feb 15.
Article en En | MEDLINE | ID: mdl-31730978
This study aimed to investigate the effect of resistant starch from green banana (GB) on steatosis and short-chain fatty acid (SCFAs) production in high fat diet-induced obesity in mice. High-fat green banana group (HFB) exhibited lower gains in BM (body mass; -6%; P < 0.01) compared with High-fat diet group (HF). Additionally, HFB mice showed reduction in liver steatosis (-28%, P < 0.01) with reduction of 93% in hepatic triacylglycerol (P < 0.01) compared to HF-diet-fed mice. In addition, the protein abundance of AMPKp/AMPK, HMGCoA-r and FAS were downregulated in livers of HFB mice (P < 0.01), relatively to the HF-diet-fed mice. ABCG8 and ABCG5 were up-regulated in HFB group compared to HF group (P < 0.01). Furthermore, the HFB fed-mice produced the highest amount of SCFAs (p < 0.05) compared to its counterpart HFD. In conclusion, we demonstrated that resistant starch from GB improved metabolic parameters by modulating the expression of key proteins involved in liver lipid metabolism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Almidón / Carbohidratos de la Dieta / Musa / Ácidos Grasos Volátiles / Dieta Alta en Grasa / Enfermedad del Hígado Graso no Alcohólico Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Almidón / Carbohidratos de la Dieta / Musa / Ácidos Grasos Volátiles / Dieta Alta en Grasa / Enfermedad del Hígado Graso no Alcohólico Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos