Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y<sub>2</sub> and GPR17.

Pillaiyar, Thanigaimalai; Funke, Mario; Al-Hroub, Haneen; Weyler, Stefanie; Ivanova, Sabrina; Schlegel, Jonathan; Abdelrahman, Aliaa; Müller, Christa E

Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y₂ and GPR17.

Pillaiyar, Thanigaimalai; Funke, Mario; Al-Hroub, Haneen; Weyler, Stefanie; Ivanova, Sabrina; Schlegel, Jonathan; Abdelrahman, Aliaa; Müller, Christa E.

Afiliación

Pillaiyar T; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Funke M; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Al-Hroub H; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Weyler S; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Ivanova S; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Schlegel J; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Abdelrahman A; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany.
Müller CE; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121, Bonn, Germany. Electronic address: christa.mueller@uni-bonn.de.

Eur J Med Chem ; 186: 111789, 2020 Jan 15.

Article en En | MEDLINE | ID: mdl-31727469

Asunto(s)

Diseño de Fármacos; Receptores Acoplados a Proteínas G/antagonistas & inhibidores; Receptores Purinérgicos P2Y2/metabolismo; Suramina/farmacología; Animales; Células CHO; Cricetulus; Relación Dosis-Respuesta a Droga; Humanos; Microsomas Hepáticos/química; Microsomas Hepáticos/metabolismo; Estructura Molecular; Receptores Acoplados a Proteínas G/metabolismo; Relación Estructura-Actividad; Suramina/síntesis química; Suramina/química

Palabras clave

Dual antagonists; GPR17; Inflammatory diseases; Multi-target drugs; P2Y(2) receptor; Small molecules; Suramin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Suramina / Diseño de Fármacos / Receptores Acoplados a Proteínas G / Receptores Purinérgicos P2Y2 Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Francia

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