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Inonotus obliquus polysaccharide protects against adverse pregnancy caused by Toxoplasma gondii infection through regulating Th17/Treg balance via TLR4/NF-κB pathway.
Xu, Lu; Yu, Yifan; Sang, Rui; Ge, Bingjie; Wang, Meng; Zhou, Hongyuan; Zhang, Xuemei.
Afiliación
  • Xu L; Department of Animal Medicine, Agricultural College of Yanbian University, Gongyuan Street, Yanji, Jilin 133002, China; Department of Animal Medicine, College of Agriculture and Forestry Science, Linyi University, Shuangling Road, Linyi, Shandong 276005, China.
  • Yu Y; Department of Animal Medicine, Agricultural College of Yanbian University, Gongyuan Street, Yanji, Jilin 133002, China.
  • Sang R; Department of Animal Medicine, Agricultural College of Yanbian University, Gongyuan Street, Yanji, Jilin 133002, China.
  • Ge B; Department of Animal Medicine, Agricultural College of Yanbian University, Gongyuan Street, Yanji, Jilin 133002, China.
  • Wang M; Department of Animal Medicine, Agricultural College of Yanbian University, Gongyuan Street, Yanji, Jilin 133002, China.
  • Zhou H; Department of Animal Medicine, Agricultural College of Yanbian University, Gongyuan Street, Yanji, Jilin 133002, China.
  • Zhang X; Department of Animal Medicine, Agricultural College of Yanbian University, Gongyuan Street, Yanji, Jilin 133002, China. Electronic address: zhangxm@ybu.edu.cn.
Int J Biol Macromol ; 146: 832-840, 2020 Mar 01.
Article en En | MEDLINE | ID: mdl-31726135
The study aimed to explore the protective effects of Inonotus obliquus polysaccharide (IOP) on adverse pregnancy caused by Toxoplasma gondii (T. gondii) infection and discover its potential mechanisms in pregnant mice. Our data showed that IOP significantly reduced the abortion rate, inhibited the decreases of progesterone (P) and estriol (E3) levels and the increase of malondialdehyde (MDA) level, and increased the activities of superoxide dismutase (SOD) and glutathione (GSH). In addition, IOP inhibited the production of inflammatory cytokine tumor necrosis factor (TNF)-α, interleukin (IL)-6, interferon (IFN)-γ, IL-1ß and IL-17A; and promoted the production of anti-inflammatory cytokine IL-10 and transforming growth factor (TGF)-ß in T. gondii-infected pregnant mice. Furthermore, IOP effectively up-regulated the expression of forkhead box (Fox)p3, whereas down-regulated the expressions of retinoic acid-related orphan receptor (ROR)γt, signal transducer and activator of transcription (STAT)3 and toll-like receptor (TLR)4, and inhibited the phosphorylations of nuclear factor-κappaB (NF-κB) p65 and inhibitor kappa(Iκ)Bα in placental tissues with T. gondii-infected mice. These findings demonstrate that IOP exerts protective effects against adverse pregnancy caused by T. gondii infection in mice by promoting the balance of T helper (Th)17/regulatory T (Treg) through regulating TLR4/NF-κB pathway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Toxoplasma / Toxoplasmosis / FN-kappa B / Complicaciones Parasitarias del Embarazo / Linfocitos T Reguladores / Receptor Toll-Like 4 / Células Th17 Límite: Animals / Pregnancy Idioma: En Revista: Int J Biol Macromol Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Toxoplasma / Toxoplasmosis / FN-kappa B / Complicaciones Parasitarias del Embarazo / Linfocitos T Reguladores / Receptor Toll-Like 4 / Células Th17 Límite: Animals / Pregnancy Idioma: En Revista: Int J Biol Macromol Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos