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A Class of FeIII Macrocyclic Complexes with Alcohol Donor Groups as Effective T1 MRI Contrast Agents.
Snyder, Eric M; Asik, Didar; Abozeid, Samira M; Burgio, Ariel; Bateman, Gage; Turowski, Steven G; Spernyak, Joseph A; Morrow, Janet R.
Afiliación
  • Snyder EM; Department of Chemistry, University at Buffalo, State University of New York, Amherst, New York, 14260, USA.
  • Asik D; Department of Chemistry, University at Buffalo, State University of New York, Amherst, New York, 14260, USA.
  • Abozeid SM; Department of Chemistry, University at Buffalo, State University of New York, Amherst, New York, 14260, USA.
  • Burgio A; Department of Chemistry, University at Buffalo, State University of New York, Amherst, New York, 14260, USA.
  • Bateman G; Department of Chemistry, University at Buffalo, State University of New York, Amherst, New York, 14260, USA.
  • Turowski SG; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, 14263, USA.
  • Spernyak JA; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, 14263, USA.
  • Morrow JR; Department of Chemistry, University at Buffalo, State University of New York, Amherst, New York, 14260, USA.
Angew Chem Int Ed Engl ; 59(6): 2414-2419, 2020 02 03.
Article en En | MEDLINE | ID: mdl-31725934
Early studies suggested that FeIII complexes cannot compete with GdIII complexes as T1 MRI contrast agents. Now it is shown that one member of a class of high-spin macrocyclic FeIII complexes produces more intense contrast in mice kidneys and liver at 30 minutes post-injection than does a commercially used GdIII agent and also produces similar T1 relaxivity in serum phantoms at 4.7 T and 37 °C. Comparison of four different FeIII macrocyclic complexes elucidates the factors that contribute to relaxivity in vivo including solution speciation. Variable-temperature 17 O NMR studies suggest that none of the complexes has a single, integral inner-sphere water that exchanges rapidly on the NMR timescale. MRI studies in mice show large in vivo differences of three of the FeIII complexes that correspond, in part, to their r1 relaxivity in phantoms. Changes in overall charge of the complex modulate contrast enhancement, especially of the kidneys.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Compuestos Férricos / Medios de Contraste / Complejos de Coordinación Límite: Animals Idioma: En Revista: Angew Chem Int Ed Engl Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Compuestos Férricos / Medios de Contraste / Complejos de Coordinación Límite: Animals Idioma: En Revista: Angew Chem Int Ed Engl Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania