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Epigenetic aging in children from a small-scale farming society in The Congo Basin: Associations with child growth and family conflict.
Gettler, Lee T; Lin, David T S; Miegakanda, Valchy; Lew-Levy, Sheina; Eick, Geeta N; Snodgrass, J Josh; MacIsaac, Julia L; Ramadori, Katia E; Kobor, Michael S; Boyette, Adam H.
Afiliación
  • Gettler LT; Department of Anthropology, University of Notre Dame, Notre Dame, IN, USA.
  • Lin DTS; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, USA.
  • Miegakanda V; William J. Shaw Center for Children and Families, University of Notre Dame, South Bend, IN, USA.
  • Lew-Levy S; BC Children's Hospital Research, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
  • Eick GN; Institut National de Santé Publique, Brazzaville, Republic of the Congo.
  • Snodgrass JJ; Department of Psychology, Simon Fraser University, Burnaby, Canada.
  • MacIsaac JL; Department of Anthropology, University of Oregon, Eugene, OR, USA.
  • Ramadori KE; Department of Anthropology, University of Oregon, Eugene, OR, USA.
  • Kobor MS; BC Children's Hospital Research, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
  • Boyette AH; BC Children's Hospital Research, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Dev Psychobiol ; 62(2): 138-153, 2020 03.
Article en En | MEDLINE | ID: mdl-31724171
Developmental environments influence individuals' long-term health trajectories, and there is increasing emphasis on understanding the biological pathways through which this occurs. Epigenetic aging evaluates DNA methylation at a suite of distinct CpG sites in the genome, and epigenetic age acceleration (EAA) is linked to heightened chronic morbidity and mortality risks in adults. Consequently, EAA provides insights on trajectories of biological aging, which early life experiences may help shape. However, few studies have measured correlates of children's epigenetic aging, especially outside of the U.S. and Europe. In particular, little is known about how children's growth and development relate to EAA in ecologies in which energetic and pathogenic stressors are commonplace. We studied EAA from dried blood spots among Bondongo children (n = 54) residing in a small-scale, fisher-farmer society in a remote region of the Republic of the Congo. Here, infectious disease burdens and their resultant energy demands are high. Children who were heavier for height or taller for age, respectively, exhibited greater EAA, including intrinsic EAA, which is considered to measure EAA internal to cells. Furthermore, we found that children in families with more conflict between parents had greater intrinsic EAA. These results suggest that in contexts in which limited energy must be allocated to competing demands, more investment in growth may coincide with greater EAA, which parallels findings in European children who do not face similar energetic constraints. Our findings also indicate that associations between adverse family environments and greater intrinsic EAA were nonetheless observable but only after adjustment for covariates relevant to the energetically and immunologically demanding nature of the local ecology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Envejecimiento / Desarrollo Infantil / Metilación de ADN / Desarrollo del Adolescente / Epigénesis Genética / Conflicto Familiar / Experiencias Adversas de la Infancia Tipo de estudio: Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: Dev Psychobiol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Envejecimiento / Desarrollo Infantil / Metilación de ADN / Desarrollo del Adolescente / Epigénesis Genética / Conflicto Familiar / Experiencias Adversas de la Infancia Tipo de estudio: Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: Dev Psychobiol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos