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Expression of dNK cells and their cytokines in twin pregnancies with preeclampsia.
Agra, Isabela K R; Liao, Adolfo W; Hoshida, Mara S; Schultz, Regina; Toscano, Marcello P; Francisco, Rossana P V; Zugaib, Marcelo; Brizot, Maria L.
Afiliación
  • Agra IKR; Departamento de Ginecologia e Obstetricia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Liao AW; Departamento de Ginecologia e Obstetricia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Hoshida MS; Departamento de Ginecologia e Obstetricia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Schultz R; Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Toscano MP; Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Francisco RPV; Departamento de Ginecologia e Obstetricia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Zugaib M; Departamento de Ginecologia e Obstetricia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
  • Brizot ML; Departamento de Ginecologia e Obstetricia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
Clinics (Sao Paulo) ; 74: e1200, 2019.
Article en En | MEDLINE | ID: mdl-31721933
OBJECTIVES: To assess the expression of decidual natural killer (dNK) cells and their cytokines in twin pregnancies with preeclampsia. METHODS: This was a prospective case-control study. The inclusion criteria were diamniotic (monochorionic or dichorionic) twin pregnancies in the third trimester with negative serological results for infectious diseases; absence of major fetal abnormalities or twin-twin transfusion syndrome; and no history of administration of corticosteroids in this pregnancy. The control group (CG) included uncomplicated twin pregnancies, and the preeclampsia group (PEG) included twin gestations with clinical and laboratory confirmation of the disease according to well-established criteria. Samples of the decidua were obtained and analyzed by immunohistochemistry for the expression of dNK cells and interleukins (ILs) 10, 12 and 15. In addition, maternal serum samples were collected to determine the levels of these interleukins. RESULTS: Thirty twin pregnancies were selected: 20 in the control group (CG) and 10 in the preeclampsia group (PEG). The PEG showed strong placental immunostaining for IL-15 (p=0.001) and high maternal serum levels of IL-10 (22.7 vs. 11.9 pg/mL, p=0.024) and IL-15 (15.9 vs. 7.4 pg/mL, p=0.024). CONCLUSION: A higher maternal serum concentration of both pro- and anti-inflammatory factors was observed in the twin pregnancies in the PEG. However, no difference in placental expression of IL-10 was found between the groups. These findings may suggest that maternal attempts to balance these interleukins were not sufficient to cause a placental response, and this failure may contribute to the development of preeclampsia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Células Asesinas Naturales / Citocinas / Decidua Tipo de estudio: Observational_studies Límite: Adolescent / Adult / Female / Humans / Middle aged / Pregnancy Idioma: En Revista: Clinics (Sao Paulo) Asunto de la revista: MEDICINA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preeclampsia / Células Asesinas Naturales / Citocinas / Decidua Tipo de estudio: Observational_studies Límite: Adolescent / Adult / Female / Humans / Middle aged / Pregnancy Idioma: En Revista: Clinics (Sao Paulo) Asunto de la revista: MEDICINA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos