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Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy.
Nitschkowski, Dörte; Marwitz, Sebastian; Kotanidou, Sousana A; Reck, Martin; Kugler, Christian; Rabe, Klaus F; Ammerpohl, Ole; Goldmann, Torsten.
Afiliación
  • Nitschkowski D; Pathology of the University Medical Center Schleswig-Holstein, Campus Lübeck and the Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
  • Marwitz S; LungenClinic Großhansdorf, Großhansdorf, Germany.
  • Kotanidou SA; Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Großhansdorf, Germany.
  • Reck M; Pathology of the University Medical Center Schleswig-Holstein, Campus Lübeck and the Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
  • Kugler C; Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Großhansdorf, Germany.
  • Rabe KF; Pathology of the University Medical Center Schleswig-Holstein, Campus Lübeck and the Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
  • Ammerpohl O; Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Großhansdorf, Germany.
  • Goldmann T; LungenClinic Großhansdorf, Großhansdorf, Germany.
Clin Epigenetics ; 11(1): 157, 2019 11 12.
Article en En | MEDLINE | ID: mdl-31718698
Recently, it was shown that the epigenetic age of non-small cell lung cancer (NSCLC) tissues is different from the chronological age of patients. Here, we demonstrate that Regucalcin and Survivin, molecules which are known to be involved in the process of aging and overcoming aging, are epigenetically modified in NSCLC tissues compared to corresponding tumor-free tissues from the same donors by using methylome bead chip and corresponding transcriptome analyses. A high expression of Survivin on the RNA level was negatively correlated with patients' survival in adenocarcinomas while a high Regucalcin expression was correlated positively. In stage 1 adenocarcinomas, this separation is even sharper for both genes. Within these, adenocarcinomas, smokers with low expression of Survivin show a better outcome, while the high expression of Regucalcin seems to be protective in never smokers. On the protein level, these molecules were detected by immunohistochemistry using tissue microarrays. Since Survivin can be secreted and we observed a high abundance of the protein also in the adjacent immune cells of the tumor microenvironment, an effect on benign cells can be assumed. These findings show that epigenetic re-programming of Survivin and Regucalcin in non-small cell lung cancer leads to enhanced expression of Survivin and reduced expression of Regucalcin, with a possible role of both molecules as predictive markers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Unión al Calcio / Fumar / Carcinoma de Pulmón de Células no Pequeñas / Metilación de ADN / Péptidos y Proteínas de Señalización Intracelular / Survivin / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Epigenetics Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Unión al Calcio / Fumar / Carcinoma de Pulmón de Células no Pequeñas / Metilación de ADN / Péptidos y Proteínas de Señalización Intracelular / Survivin / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Epigenetics Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania