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Life without a brain: Neuroradiological and behavioral evidence of neuroplasticity necessary to sustain brain function in the face of severe hydrocephalus.
Ferris, C F; Cai, X; Qiao, J; Switzer, B; Baun, J; Morrison, T; Iriah, S; Madularu, D; Sinkevicius, K W; Kulkarni, P.
Afiliación
  • Ferris CF; Center for Translational NeuroImaging, Northeastern University, Boston, MA, USA. C.Ferris@northeastern.edu.
  • Cai X; Center for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
  • Qiao J; Center for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
  • Switzer B; NeuroScience Associates, Knoxville, TN, USA.
  • Baun J; NeuroScience Associates, Knoxville, TN, USA.
  • Morrison T; Center for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
  • Iriah S; Center for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
  • Madularu D; Center for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
  • Sinkevicius KW; Alexion Pharmaceuticals, New Heaven, CT, USA.
  • Kulkarni P; Center for Translational NeuroImaging, Northeastern University, Boston, MA, USA.
Sci Rep ; 9(1): 16479, 2019 11 11.
Article en En | MEDLINE | ID: mdl-31712649
A two-year old rat, R222, survived a life-time of extreme hydrocephaly affecting the size and organization of its brain. Much of the cortex was severely thinned and replaced by cerebrospinal fluid, yet R222 had normal motor function, could hear, see, smell, and respond to tactile stimulation. The hippocampus was malformed and compressed into the lower hindbrain together with the hypothalamus midbrain and pons, yet R222 showed normal spatial memory as compared to age-matched controls. BOLD MRI was used to study the reorganization of R222's brain function showing global activation to visual, olfactory and tactile stimulation, particularly in the brainstem/cerebellum. The results are discussed in the context of neuroadaptation in the face of severe hydrocephaly and subsequent tissue loss, with an emphasis on what is the "bare minimum" for survival.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Encéfalo / Neuroimagen Funcional / Plasticidad Neuronal Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Encéfalo / Neuroimagen Funcional / Plasticidad Neuronal Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido