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A phase 1 dose-escalation study of checkpoint kinase 1 (CHK1) inhibitor prexasertib in combination with p38 mitogen-activated protein kinase (p38 MAPK) inhibitor ralimetinib in patients with advanced or metastatic cancer.
Bendell, Johanna C; Bischoff, Helge G; Hwang, Jimmy; Reinhardt, Hans Christian; Zander, Thomas; Wang, Xuejing; Hynes, Scott; Pitou, Celine; Campbell, Robert; Iversen, Philip; Farrington, Daphne L; Bell-McGuinn, Katherine; Thomas, Michael.
Afiliación
  • Bendell JC; Sarah Cannon Research Institute, Tennessee Oncology PLLC, 250 25th Avenue N, Suite 200, Nashville, TN, 37203, USA. jbendell@tnonc.com.
  • Bischoff HG; Department of Thoracic Oncology, Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg University Hospital, 69126, Heidelberg, Germany.
  • Hwang J; Levine Cancer Institute, Atrium Health, Charlotte, NC, USA.
  • Reinhardt HC; University of Cologne, University Hospital Cologne, Clinic I for Internal Medicine, Weyertal 115B, 50931, Cologne, Germany.
  • Zander T; University of Cologne, Center for Molecular Medicine Cologne, Rober Koch Str. 21, 50931, Cologne, Germany.
  • Wang X; Clinic I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
  • Hynes S; Eli Lilly and Company, Indianapolis, IN, USA.
  • Pitou C; Eli Lilly and Company, Indianapolis, IN, USA.
  • Campbell R; Eli Lilly and Company, Indianapolis, IN, USA.
  • Iversen P; Eli Lilly and Company, Indianapolis, IN, USA.
  • Farrington DL; Eli Lilly and Company, Indianapolis, IN, USA.
  • Bell-McGuinn K; Eli Lilly and Company, Indianapolis, IN, USA.
  • Thomas M; Verastem Oncology, Needham, MA, USA.
Invest New Drugs ; 38(4): 1145-1155, 2020 08.
Article en En | MEDLINE | ID: mdl-31707688
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazinas / Pirazoles / Piridinas / Protocolos de Quimioterapia Combinada Antineoplásica / Proteínas Quinasas p38 Activadas por Mitógenos / Inhibidores de Proteínas Quinasas / Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1) / Imidazoles / Neoplasias / Antineoplásicos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazinas / Pirazoles / Piridinas / Protocolos de Quimioterapia Combinada Antineoplásica / Proteínas Quinasas p38 Activadas por Mitógenos / Inhibidores de Proteínas Quinasas / Quinasa 1 Reguladora del Ciclo Celular (Checkpoint 1) / Imidazoles / Neoplasias / Antineoplásicos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos