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Implications of the putamen in pain and motor deficits in complex regional pain syndrome.
Azqueta-Gavaldon, Monica; Youssef, Andrew M; Storz, Claudia; Lemme, Jordan; Schulte-Göcking, Heike; Becerra, Lino; Azad, Shahnaz C; Reiners, Anselm; Ertl-Wagner, Birgit; Borsook, David; Upadhyay, Jaymin; Kraft, Eduard.
Afiliación
  • Azqueta-Gavaldon M; Department of Orthopedics, Physical Medicine and Rehabilitation, University Hospital LMU Munich, Munich, Germany.
  • Youssef AM; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
  • Storz C; Department of Orthopedics, Physical Medicine and Rehabilitation, University Hospital LMU Munich, Munich, Germany.
  • Lemme J; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
  • Schulte-Göcking H; Department of Orthopedics, Physical Medicine and Rehabilitation, University Hospital LMU Munich, Munich, Germany.
  • Becerra L; Interdisciplinary Pain Unit, University Hospital LMU Munich, Munich, Germany.
  • Azad SC; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
  • Reiners A; Interdisciplinary Pain Unit, University Hospital LMU Munich, Munich, Germany.
  • Ertl-Wagner B; Department of Rehabilitation Medicine, City Hospital Bogenhausen, Munich, Germany.
  • Borsook D; Department of Radiology, University Hospital LMU Munich, Munich, Germany.
  • Upadhyay J; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
  • Kraft E; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Pain ; 161(3): 595-608, 2020 03.
Article en En | MEDLINE | ID: mdl-31693538
Complex regional pain syndrome (CRPS) develops after-limb injury, with persistent pain and deficits in movement frequently co-occurring. The striatum is critical for mediating multiple mechanisms that are often aberrant in CRPS, which includes sensory and pain processing, motor function, and goal-directed behaviors associated with movement. Yet, much remains unknown with regards to the morphological and functional properties of the striatum and its subregions in this disease. Thus, we investigated 20 patients (15 female, age 58 ± 9 years, right-handed) diagnosed with chronic (6+ months of pain duration) CRPS in the right hand and 20 matched, healthy controls with anatomical and resting-state, functional magnetic resonance imaging. In addition, a comprehensive clinical and behavioral evaluation was performed, where each participant's pain, motor function, and medical history were assessed. Complex regional pain syndrome patients harbored significant abnormalities in hand coordination, dexterity, and strength. These clinical pain- and movement-related findings in CRPS patients were concomitant with bilateral decreases in gray matter density in the putamen as well as functional connectivity increases and decreases among the putamen and pre-/postcentral gyri and cerebellum, respectively. Importantly, higher levels of clinical pain and motor impairment were associated with increased putamen-pre-/postcentral gyri functional connectivity strengths. Collectively, these findings suggest that putaminal alterations, specifically the functional interactions with sensorimotor structures, may underpin clinical pain and motor impairment in chronic CRPS patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Putamen / Dimensión del Dolor / Trastornos de la Destreza Motora / Síndromes de Dolor Regional Complejo Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pain Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Putamen / Dimensión del Dolor / Trastornos de la Destreza Motora / Síndromes de Dolor Regional Complejo Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pain Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos