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Complication rate after cystectomy following pelvic radiotherapy: an international, multicenter, retrospective series of 682 cases.
Gontero, Paolo; Pisano, Francesca; Palou, Joan; Joniau, Steven; Albersen, Maarten; Colombo, Renzo; Briganti, Alberto; Pellucchi, Federico; Faba, Oscar Rodriguez; van Rhijn, Bas W; van de Putte, Elies Fransen; Babjuk, Marko; Fritsche, Hanz Martin; Mayr, Roman; Albers, Peter; Niegisch, Gunter; Anract, Julien; Masson-Lecomte, Alexandra; De la Taille, Alexandre; Roupret, Morgan; Peyronnet, Benoit; Cai, Tomaso; Witjes, Alfred J; Bruins, Max; Baniel, Jack; Mano, Roy; Lapini, Alberto; Sessa, Francesco; Irani, Jaques; Brausi, Maurizio; Stenzl, Arnulf; Karnes, Jeffrey R; Scherr, Douglas; O'Malley, Padraic; Taylor, Benjamin; Shariat, Shahrokh F; Black, Peter; Abdi, Hamidreza; Matveev, Vsevolod B; Samuseva, Olga; Parekh, Dipen; Gonzalgo, Mark; Vetterlein, Malte W; Aziz, Atiqullah; Fisch, Margit; Catto, James; Pang, Karl H; Xylinas, Evanguelos; Rink, Michael.
Afiliación
  • Gontero P; Department of Urology, Molinette Hospital, University of Torino School of Medicine, Turin, Italy.
  • Pisano F; Department of Urology, Molinette Hospital, University of Torino School of Medicine, Turin, Italy. francescapisano85@gmail.com.
  • Palou J; Department of Uro-oncolgy, Fundacio Puigvert, University of Barcelona, Barcelona, Spain. francescapisano85@gmail.com.
  • Joniau S; Department of Uro-oncolgy, Fundacio Puigvert, University of Barcelona, Barcelona, Spain.
  • Albersen M; Oncologic and Reconstructive Urology, Department of Urology, University Hospitals Leuven, Louvain, Belgium.
  • Colombo R; Oncologic and Reconstructive Urology, Department of Urology, University Hospitals Leuven, Louvain, Belgium.
  • Briganti A; Unit of Urology/Division of Oncology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Pellucchi F; Unit of Urology/Division of Oncology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.
  • Faba OR; Unit of Urology/Division of Oncology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.
  • van Rhijn BW; Department of Uro-oncolgy, Fundacio Puigvert, University of Barcelona, Barcelona, Spain.
  • van de Putte EF; Netherland Cancer Institute, Amsterdam, The Netherlands.
  • Babjuk M; Netherland Cancer Institute, Amsterdam, The Netherlands.
  • Fritsche HM; Department of Urology, Motol Hospital, University of Praha, Prague, Czech Republic.
  • Mayr R; Department of Urology, Regensburg University, Regensburg, Germany.
  • Albers P; Department of Urology, Regensburg University, Regensburg, Germany.
  • Niegisch G; Department of Urology, Heinrich-Heine-University, Medical Faculty, Düsseldorf, Germany.
  • Anract J; Department of Urology, Heinrich-Heine-University, Medical Faculty, Düsseldorf, Germany.
  • Masson-Lecomte A; Department of Urology, CHU Bichat, Paris, France.
  • De la Taille A; Department of Urology, Hôpital Saint-Louis, Université Paris-Diderot, Paris, France.
  • Roupret M; Department of Urology, Henri Mondor Academic Hospital, Creteil, France.
  • Peyronnet B; Department of Urology, Hôpital La Pitié-Salpétrière, Paris 6 University, Paris, France.
  • Cai T; Department of Urology, Hôpital La Pitié-Salpétrière, Paris 6 University, Paris, France.
  • Witjes AJ; Department of Urology, Ospedale S. Chiara, Trento, Italy.
  • Bruins M; Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
  • Baniel J; Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
  • Mano R; Department of Urology, Rabin Medical Centre, Tel Aviv, Israel.
  • Lapini A; Department of Urology, Rabin Medical Centre, Tel Aviv, Israel.
  • Sessa F; Department of Urology, University of Florence, University Hospital of Florence, Florence, Italy.
  • Irani J; Department of Urology, University of Florence, University Hospital of Florence, Florence, Italy.
  • Brausi M; Department of Urology, Kremlin-Bicetre Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.
  • Stenzl A; Department of Urology, Ospedale di Carpi-Modena, Modena, Italy.
  • Karnes JR; Department of Urology, University Hospital Tübingen, Tübingen, Germany.
  • Scherr D; Department of Urology, Mayo Clinic, Rochester, USA.
  • O'Malley P; Department of Urology, Weill Cornell Medical College, New York, USA.
  • Taylor B; Department of Urology, Weill Cornell Medical College, New York, USA.
  • Shariat SF; Department of Urology, Weill Cornell Medical College, New York, USA.
  • Black P; Department of Urology, Medical University of Vienna, Vienna, Austria.
  • Abdi H; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Matveev VB; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Samuseva O; Department of Urology, N.N. Blokhin Russian Cancer Research Center, Moscow, Russia.
  • Parekh D; Department of Urology, N.N. Blokhin Russian Cancer Research Center, Moscow, Russia.
  • Gonzalgo M; Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Vetterlein MW; Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Aziz A; Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Fisch M; Department of Urology, University Medical Center Rostock, Rostock, Germany.
  • Catto J; Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Pang KH; Academic Urology Unit, University of Sheffield, Sheffield, UK.
  • Xylinas E; Academic Urology Unit, University of Sheffield, Sheffield, UK.
  • Rink M; Department of Urology, CHU Bichat, Paris, France.
World J Urol ; 38(8): 1959-1968, 2020 Aug.
Article en En | MEDLINE | ID: mdl-31691084
PURPOSE: Conflicting evidence exists on the complication rates after cystectomy following previous radiation (pRTC) with only a few available series. We aim to assess the complication rate of pRTC for abdominal-pelvic malignancies. METHODS: Patients treated with radical cystectomy following any previous history of RT and with available information on complications for a minimum of 1 year were included. Univariable and multivariable logistic regression models were used to assess the relationship between the variable parameters and the risk of any complication. RESULTS: 682 patients underwent pRTC after a previous RT (80.5% EBRT) for prostate, bladder (BC), gynecological or other cancers in 49.1%, 27.4%, 9.8% and 12.9%, respectively. Overall, 512 (75.1%) had at least one post-surgical complication, classified as Clavien ≥ 3 in 29.6% and Clavien V in 2.9%. At least one surgical complication occurred in 350 (51.3%), including bowel leakage in 6.2% and ureteric stricture in 9.4%. A medical complication was observed in 359 (52.6%) patients, with UTI/pyelonephritis being the most common (19%), followed by renal failure (12%). The majority of patients (86%) received an incontinent urinary diversion. In multivariable analysis adjusted for age, gender and type of RT, patients treated with RT for bladder cancer had a 1.7 times increased relative risk of experiencing any complication after RC compared to those with RT for prostate cancer (p = 0.023). The type of diversion (continent vs non-continent) did not influence the risk of complications. CONCLUSION: pRTC carries a high rate of major complications that dramatically exceeds the rates reported in RT-naïve RCs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Vejiga Urinaria / Neoplasias de la Vejiga Urinaria / Cistectomía / Neoplasias Abdominales Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: World J Urol Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Vejiga Urinaria / Neoplasias de la Vejiga Urinaria / Cistectomía / Neoplasias Abdominales Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: World J Urol Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania