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5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms.
Frohock, Bram H; Gilbertie, Jessica M; Daiker, Jennifer C; Schnabel, Lauren V; Pierce, Joshua G.
Afiliación
  • Frohock BH; Department of Chemistry, College of Sciences, NC State University, 2620 Yarbrough Drive, Raleigh, NC, 27695, USA.
  • Gilbertie JM; Comparative Medicine Institute, NC State University, Raleigh, NC, 27607, USA.
  • Daiker JC; Department of Clinical Sciences, College of Veterinary Medicine, NC State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
  • Schnabel LV; Comparative Medicine Institute, NC State University, Raleigh, NC, 27607, USA.
  • Pierce JG; Department of Chemistry, College of Sciences, NC State University, 2620 Yarbrough Drive, Raleigh, NC, 27695, USA.
Chembiochem ; 21(7): 933-937, 2020 04 01.
Article en En | MEDLINE | ID: mdl-31688982
The failure of frontline antibiotics in the clinic is one of the most serious threats to human health and requires a multitude of novel therapeutics and innovative approaches to treatment so as to curtail the growing crisis. In addition to traditional resistance mechanisms resulting in the lack of efficacy of many antibiotics, most chronic and recurring infections are further made tolerant to antibiotic action by the presence of biofilms. Herein, we report an expanded set of 5-benzylidene-4-oxazolidinones that are able to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilms, and, in combination with common antibiotics, are able to significantly reduce the bacterial load in a robust collagen-matrix model of biofilm infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Compuestos de Bencilideno / Biopelículas / Oxazolidinonas / Antibacterianos Idioma: En Revista: Chembiochem Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Compuestos de Bencilideno / Biopelículas / Oxazolidinonas / Antibacterianos Idioma: En Revista: Chembiochem Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania