[Progress in genomic DNA methylation of esophageal squamous cell carcinoma].

Guo, J; Hao, J J; Wang, M R

Guo, J; Hao, J J; Wang, M R.

Afiliación

Guo J; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Zhonghua Yu Fang Yi Xue Za Zhi ; 53(11): 1176-1182, 2019 Nov 06.

Article en Zh | MEDLINE | ID: mdl-31683410

RESUMEN

Abnormal genomic DNA methylation is an important epigenetic change in malignant tumors. Esophageal squamous cell cancer is one of common malignant tumors in our country. In this paper summarized and discussed the progress of genomic DNA methylation in the esophageal squamouscell cancer, including the level of genomic DNA methylation, frequent abnormally methylated genes, methylation markers and potential targets, etc. This paper might provide candidate biomarkers and targets for further studies on the mechanism of the tumorigenesis and development of the esophagealsquamouscell cancer, as well as for the clinical application of esophageal cancer.

Asunto(s)

Metilación de ADN; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/patología; Carcinoma de Células Escamosas de Esófago/genética; Carcinoma de Células Escamosas de Esófago/patología; Biomarcadores de Tumor; Epigénesis Genética; Genómica; Humanos; Regiones Promotoras Genéticas

Palabras clave

Biomarkers; Esophageal neoplasms; Genome; Methylation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Metilación de ADN / Carcinoma de Células Escamosas de Esófago Límite: Humans Idioma: Zh Revista: Zhonghua Yu Fang Yi Xue Za Zhi Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: China

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