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Preparation of microemulsion containing Lycopersicon esculentum extract: In vitro characterization and stability studies.
Parveen, Rashida; Akhtar, Naveed; Farooq, Muhammad Asim; Ghayas, Sana; Bushra, Rabia; Khan, Daulat Haleem; Aquib, M D.
Afiliación
  • Parveen R; Department of Pharmacy, Superior University Lahore, Pakistan.
  • Akhtar N; Department of Pharmacy, Faculty of Pharmacy and alternative medicine, The Islamia University of Bahawalpur, Pakistan.
  • Farooq MA; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing Jiangsu, PR China.
  • Ghayas S; Department of Pharmaceutics, Faculty of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan.
  • Bushra R; Department of Pharmaceutics, Faculty of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan.
  • Khan DH; Department of Pharmacy, Lahore College of Pharmaceutical Sciences, Lahore, Pakistan.
  • Aquib MD; Department of Pharmacy, Faculty of Pharmacy and alternative medicine, The Islamia University of Bahawalpur, Pakistan.
Pak J Pharm Sci ; 32(4(Supplementary)): 1821-1827, 2019 Jul.
Article en En | MEDLINE | ID: mdl-31680078
Lycopene, the active component of Lycopersicon esculentum species, has been reported for the protecting capabilities against ultra-violet induced skin pigmentation, antioxygen and antityrosinase activities. In the present study, extract of tomato fruit was obtained from the Lycopersicon esculentum plant using solvent system comprised of hexaneethanol-acetone. The phyto chemical active constituent lycopene was then identified by spectrophotometric technique at 470nm. Micro emulsions were developed containing different ratio of water, isopropyl myristate (oil), tween 80 and propylene glycol as surfactant and co-surfactant respectively via pseudoternary phase diagram. Various physicochemical tests were performed including globular size, conductivity, viscosity, scanning electron microscopy (SEM), refractive index (RI) and pH measurement for the formulation characterization. Results of physical and chemical stability studies showed that the micro emulsion with proportion of surfactant: co-surfactant of 2:1 (Smix) was found to be optimized formulation and with enhanced stability. Therefore, concluded that the stability of the micro emulsion was dependent on the proportions of surfactant co-surfactant, water and oil in the preparation.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Solanum lycopersicum / Emulsiones Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Solanum lycopersicum / Emulsiones Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán