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AIE-active polysiloxane-based fluorescent probe for identifying cancer cells by locating lipid drops.
Yang, Tingxin; Zuo, Yujing; Zhang, Yu; Gou, Zhiming; Wang, Xiaoni; Lin, Weiying.
Afiliación
  • Yang T; Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Shandong, 250022, PR China.
  • Zuo Y; Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Shandong, 250022, PR China.
  • Zhang Y; Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Shandong, 250022, PR China.
  • Gou Z; Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Shandong, 250022, PR China.
  • Wang X; Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Shandong, 250022, PR China.
  • Lin W; Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Shandong, 250022, PR China. Electronic address: weiyinglin2013@163.com.
Anal Chim Acta ; 1091: 88-94, 2019 Dec 24.
Article en En | MEDLINE | ID: mdl-31679578
Comparing with normal cells, Lipid droplets (LDs) of cancer cells show lower polarity and less quantity, which can be utilized as a marker for cancer diagnosis. However, the investigation of LDs in living cancer cells is restricted by the lack of effective molecular tools. Herein, we first reported a novel polysiloxane-based polymer fluorescent polar probe TR-1 with AIE properties, which realized the possibilities for locating LDs. It can aggregate in the LDs of cancer cells and show a stronger fluorescent signal to conduct cancer diagnosis. Moreover, the excellent photostability of TR-1 enable stable fluorescence to exhibit in cancer cells during effective time.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Siloxanos / Gotas Lipídicas / Colorantes Fluorescentes / Neoplasias Límite: Animals / Humans Idioma: En Revista: Anal Chim Acta Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Siloxanos / Gotas Lipídicas / Colorantes Fluorescentes / Neoplasias Límite: Animals / Humans Idioma: En Revista: Anal Chim Acta Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos