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An antibiotic depleted microbiome drives severe Campylobacter jejuni-mediated Type 1/17 colitis, Type 2 autoimmunity and neurologic sequelae in a mouse model.
Brooks, Phillip T; Bell, Julia A; Bejcek, Christopher E; Malik, Ankit; Mansfield, Linda S.
Afiliación
  • Brooks PT; Comparative Enteric Diseases Laboratory, Michigan State University, East Lansing, MI, USA; Comparative Medicine Integrative Biology Graduate Program, Michigan State University, East Lansing, MI, USA; College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA; Institute for Inte
  • Bell JA; Comparative Enteric Diseases Laboratory, Michigan State University, East Lansing, MI, USA; Departments of Microbiology and Molecular Genetics and Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA; College of Veterinary Medicine, Michigan State University, East Lansing,
  • Bejcek CE; Comparative Enteric Diseases Laboratory, Michigan State University, East Lansing, MI, USA; Departments of Microbiology and Molecular Genetics and Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA.
  • Malik A; Comparative Enteric Diseases Laboratory, Michigan State University, East Lansing, MI, USA; Departments of Microbiology and Molecular Genetics and Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA.
  • Mansfield LS; Comparative Enteric Diseases Laboratory, Michigan State University, East Lansing, MI, USA; Departments of Microbiology and Molecular Genetics and Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA; College of Veterinary Medicine, Michigan State University, East Lansing,
J Neuroimmunol ; 337: 577048, 2019 12 15.
Article en En | MEDLINE | ID: mdl-31678855
The peripheral neuropathy Guillain-Barré Syndrome can follow Campylobacter jejuni infection when outer core lipooligosaccharides induce production of neurotoxic anti-ganglioside antibodies. We hypothesized that gut microbiota depletion with an antibiotic would increase C. jejuni colonization, severity of gastroenteritis, and GBS. Microbiota depletion increased C. jejuni colonization, invasion, and colitis with Type 1/17 T cells in gut lamina propria. It also stimulated Type 1/17 anti-C. jejuni and -antiganglioside-antibodies, Type 2 anti-C. jejuni and -antiganglioside antibodies, and neurologic phenotypes. Results indicate that both C. jejuni strain and gut microbiota affect development of inflammation and GBS and suggest that probiotics following C. jejuni infection may ameliorate inflammation and autoimmune disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Campylobacter / Autoinmunidad / Colitis / Modelos Animales de Enfermedad / Microbioma Gastrointestinal / Antibacterianos Límite: Animals Idioma: En Revista: J Neuroimmunol Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Campylobacter / Autoinmunidad / Colitis / Modelos Animales de Enfermedad / Microbioma Gastrointestinal / Antibacterianos Límite: Animals Idioma: En Revista: J Neuroimmunol Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos