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A versatile theranostic nanodevice based on an orthogonal bioconjugation strategy for efficient targeted treatment and monitoring of triple negative breast cancer.
Cano-Cortes, María Victoria; Navarro-Marchal, Saúl Abenhamar; Ruiz-Blas, María Paz; Diaz-Mochon, Juan José; Marchal, Juan Antonio; Sanchez-Martin, Rosario M.
Afiliación
  • Cano-Cortes MV; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain; Department of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry applied to Biomedicine and the Environment," Faculty of Pharmacy,
  • Navarro-Marchal SA; Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, Granada, Spain; Department of Applied Physics, Faculty of Sciences, University of Granada, Granada, Spain; Department of Human Anatomy and Embryology and Excellence Research Unit
  • Ruiz-Blas MP; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain; Department of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry applied to Biomedicine and the Environment," Faculty of Pharmacy,
  • Diaz-Mochon JJ; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain; Department of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry applied to Biomedicine and the Environment," Faculty of Pharmacy,
  • Marchal JA; Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Universidad de Granada, Granada, Spain; Department of Human Anatomy and Embryology and Excellence
  • Sanchez-Martin RM; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain; Department of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry applied to Biomedicine and the Environment," Faculty of Pharmacy,
Nanomedicine ; 24: 102120, 2020 02.
Article en En | MEDLINE | ID: mdl-31676374
A novel chemical-based orthogonal bioconjugation strategy to produce tri-functionalized nanoparticles (NPs) an chemotherapy drug, doxorubicin (DOX), a near-infrared cyanine dye (Cy7) and CRGDK homing peptide, a peptide specifically binds to neuropilin-1 (Nrp-1) overexpressed on triple negative breast cancer (TNBC) cells, has been validated. These theranostic NPs have been evaluated in vitro and in vivo using an orthotopic xenotransplant mouse model using TNBC cells. In vitro assays show that theranostic NPs improve the therapeutic index in comparison with free DOX. Remarkably, in vivo studies showed preferred location of theranostic NPs in the tumor area reducing the volume at the same level than free DOX while presenting lower side effects. This multifunctionalized theranostic nanodevice based on orthogonal conjugation strategies could be a good candidate for the treatment and monitoring of Nrp-1 overexpressing tumors. Moreover, this versatile nanodevice can be easily adapted to treat and monitor different cancer types by adapting the conjugation strategy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Carbocianinas / Doxorrubicina / Sistemas de Liberación de Medicamentos / Nanopartículas / Neoplasias de la Mama Triple Negativas / Nanomedicina Teranóstica Límite: Animals / Female / Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Carbocianinas / Doxorrubicina / Sistemas de Liberación de Medicamentos / Nanopartículas / Neoplasias de la Mama Triple Negativas / Nanomedicina Teranóstica Límite: Animals / Female / Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos