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The tribology of cartilage: Mechanisms, experimental techniques, and relevance to translational tissue engineering.
Link, Jarrett M; Salinas, Evelia Y; Hu, Jerry C; Athanasiou, Kyriacos A.
Afiliación
  • Link JM; 3131 Engineering Hall, Department of Biomedical Engineering, University of California, Irvine, CA 92617, USA. Electronic address: jarrett.link@uci.edu.
  • Salinas EY; 3131 Engineering Hall, Department of Biomedical Engineering, University of California, Irvine, CA 92617, USA. Electronic address: e.y.salinas@uci.edu.
  • Hu JC; 3131 Engineering Hall, Department of Biomedical Engineering, University of California, Irvine, CA 92617, USA. Electronic address: jerry.hu@uci.edu.
  • Athanasiou KA; 3131 Engineering Hall, Department of Biomedical Engineering, University of California, Irvine, CA 92617, USA. Electronic address: athens@uci.edu.
Clin Biomech (Bristol, Avon) ; 79: 104880, 2020 10.
Article en En | MEDLINE | ID: mdl-31676140
Diarthrodial joints, found at the ends of long bones, function to dissipate load and allow for effortless articulation. Essential to these functions are cartilages, soft hydrated tissues such as hyaline articular cartilage and the knee meniscus, as well as lubricating synovial fluid. Maintaining adequate lubrication protects cartilages from wear, but a decrease in this function leads to tissue degeneration and pathologies such as osteoarthritis. To study cartilage physiology, articular cartilage researchers have employed tribology, the study of lubrication and wear between two opposing surfaces, to characterize both native and engineered tissues. The biochemical components of synovial fluid allow it to function as an effective lubricant that exhibits shear-thinning behavior. Although tribological properties are recognized to be essential to native tissue function and a critical characteristic for translational tissue engineering, tribology is vastly understudied when compared to other mechanical properties such as compressive moduli. Further, tribometer configurations and testing modalities vary greatly across laboratories. This review aims to define commonly examined tribological characteristics and discuss the structure-function relationships of biochemical constituents known to contribute to tribological properties in native tissue, address the variations in experimental set-ups by suggesting a move toward standard testing practices, and describe how tissue-engineered cartilages may be augmented to improve their tribological properties.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cartílago Articular / Ingeniería de Tejidos / Fenómenos Mecánicos Límite: Animals / Humans Idioma: En Revista: Clin Biomech (Bristol, Avon) Asunto de la revista: ENGENHARIA BIOMEDICA / FISIOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cartílago Articular / Ingeniería de Tejidos / Fenómenos Mecánicos Límite: Animals / Humans Idioma: En Revista: Clin Biomech (Bristol, Avon) Asunto de la revista: ENGENHARIA BIOMEDICA / FISIOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido