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Chronic stress influences nociceptive sensitivity of female rats in an estrous cycle-dependent manner.
Yang, Chun-Xiao; Wang, Yi; Lu, Qi; Lian, Yan-Na; Anto, Enoch Odame; Zhang, Ying; Wang, Wei.
Afiliación
  • Yang CX; Department of Neurology of second Affiliated Hospital, Harbin Medical University, Harbin, P. R. China.
  • Wang Y; Biotechnology Experimental Teaching Center, Harbin Medical University, Harbin, P. R. China.
  • Lu Q; Department of Physiology, Harbin Medical University, Harbin, P. R. China.
  • Lian YN; Medical College, Zhejiang University, Hangzhou, P. R. China.
  • Anto EO; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
  • Zhang Y; Department of Physiology, Harbin Medical University, Harbin, P. R. China.
  • Wang W; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Stress ; 23(4): 386-392, 2020 07.
Article en En | MEDLINE | ID: mdl-31672079
Exposure to chronic stress can influence nociception and further induce hyperalgesia. Whether stress modulation of pain in female animals occurs in an estrous cycle-specific manner is still unclear. We profiled the changes in nociception (thermal, mechanical, formalin-evoked acute and inflammatory pain) of female Sprague-Dawley rats after treatment with chronic unpredictable mild stress (CUMS) and investigated whether these changes occur in an estrous cycle-dependent manner. The results showed that CUMS female rats exhibited a lower mechanical withdrawal threshold in proestrus and estrus, a longer formalin-evoked licking time in metestrus and diestrus, but no changes in the latency time on the tail-flick test. The present study findings suggest that chronic stress induces mechanical and formalin-evoked acute hyperalgesia of female rats in an estrous cycle-dependent manner.SUMMARYOur studies showed that chronic stress increased nociceptive sensitivity of female rats. Furthermore females had different stress-induced pain responses in different estrous phases: mechanical hyperalgesia in proestrus and estrus, formalin-evoked acute hyperalgesia in metestrus and diestrus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Nocicepción Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Stress Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Nocicepción Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Stress Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido