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Dynamic DNA nanostructures in biomedicine: Beauty, utility and limits.
Jahanban-Esfahlan, Ali; Seidi, Khaled; Jaymand, Mehdi; Schmidt, Thorsten L; Majdi, Hasan; Javaheri, Tahereh; Jahanban-Esfahlan, Rana; Zare, Peyman.
Afiliación
  • Jahanban-Esfahlan A; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Seidi K; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Jaymand M; Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Schmidt TL; Physics Department, 103 Smith Hall, Kent State University, Kent, OH, 44240, USA.
  • Majdi H; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Javaheri T; Ludwig Boltzmann Institute for Cancer Research, 1090 Vienna, Austria. Electronic address: zohre.javaheri@gmail.com.
  • Jahanban-Esfahlan R; Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Faculty of Medicine, Cardinal Stefan Wyszynski University in Warsaw, 01-938 Warsaw, Poland.
  • Zare P; Faculty of Medicine, Cardinal Stefan Wyszynski University in Warsaw, 01-938 Warsaw, Poland. Electronic address: peymanzare33@gmail.com.
J Control Release ; 315: 166-185, 2019 12 10.
Article en En | MEDLINE | ID: mdl-31669209
DNA composite materials are at the forefront, especially for biomedical science, as they can increase the efficacy and safety of current therapies and drug delivery systems. The specificity and predictability of the Watson-Crick base pairing make DNA an excellent building material for the production of programmable and multifunctional objects. In addition, the principle of nucleic acid hybridization can be applied to realize mobile nanostructures, such as those reflected in DNA walkers that sort and collect cargo on DNA tracks, DNA robots performing tasks within living cells and/or DNA tweezers as ultra-sensitive biosensors. In this review, we present the diversity of dynamic DNA nanostructures functionalized with different biomolecules/functional units, imaging smart biomaterials capable of sensing, interacting, delivery and performing complex tasks within living cells/organisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN / Sistemas de Liberación de Medicamentos / Nanoestructuras Límite: Animals / Humans Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN / Sistemas de Liberación de Medicamentos / Nanoestructuras Límite: Animals / Humans Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos