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Neutrophil Recruitment to Noninvasive MRSA at the Stratum Corneum of Human Skin Mediates Transient Colonization.
Schulz, Anette; Jiang, Long; de Vor, Lisanne; Ehrström, Marcus; Wermeling, Fredrik; Eidsmo, Liv; Melican, Keira.
Afiliación
  • Schulz A; Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institute, Stockholm 171 77, Sweden.
  • Jiang L; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm 171 77, Sweden.
  • de Vor L; Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institute, Stockholm 171 77, Sweden.
  • Ehrström M; Department of Reconstructive Plastic Surgery, Karolinska University Hospital Solna, Stockholm 171 77, Sweden.
  • Wermeling F; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm 171 77, Sweden.
  • Eidsmo L; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm 171 77, Sweden.
  • Melican K; Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institute, Stockholm 171 77, Sweden. Electronic address: keira.melican@ki.se.
Cell Rep ; 29(5): 1074-1081.e5, 2019 Oct 29.
Article en En | MEDLINE | ID: mdl-31665625
Staphylococcus aureus is a leading cause of skin and soft issue infection, but paradoxically, it also transiently, and often harmlessly, colonizes human skin. An obstacle to understanding this contradiction has been a shortage of in vivo models reproducing the unique structure and immunology of human skin. In this work, we developed a humanized model to study how healthy adult human skin responds to colonizing methicillin-resistant S. aureus (MRSA). We demonstrate the importance of the outer stratum corneum as the major site of bacterial colonization and how noninvasive MRSA adhesion to corneocytes induces a local inflammatory response in underlying skin layers. This signaling recruits neutrophils to the skin, where they control bacterial numbers, mediating transiency in colonization. This work highlights the spatiotemporal aspects of human skin colonization and demonstrates a subclinical inflammatory response to noninvasive MRSA that allows human skin to regulate the bacterial population at its outer surface.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Infiltración Neutrófila / Staphylococcus aureus Resistente a Meticilina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Infiltración Neutrófila / Staphylococcus aureus Resistente a Meticilina Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos