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A new human challenge model for testing heat-stable toxin-based vaccine candidates for enterotoxigenic Escherichia coli diarrhea - dose optimization, clinical outcomes, and CD4+ T cell responses.
Sakkestad, Sunniva Todnem; Steinsland, Hans; Skrede, Steinar; Lillebø, Kristine; Skutlaberg, Dag Harald; Guttormsen, Anne Berit; Zavialov, Anton; Paavilainen, Sari; Søyland, Hanne; Sævik, Marianne; Heien, Astrid Rykkje; Tellevik, Marit Gjerde; Barry, Eileen; Langeland, Nina; Sommerfelt, Halvor; Hanevik, Kurt.
Afiliación
  • Sakkestad ST; Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.
  • Steinsland H; Centre for Intervention Science in Maternal and Child Health (CISMAC), Centre for International Health, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
  • Skrede S; Department of Biomedicine, Faculty of Medicine, University of Bergen, Bergen, Norway.
  • Lillebø K; Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.
  • Skutlaberg DH; Division for Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
  • Guttormsen AB; Department of Microbiology, Haukeland University Hospital, Bergen, Norway.
  • Zavialov A; Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.
  • Paavilainen S; Department of Microbiology, Haukeland University Hospital, Bergen, Norway.
  • Søyland H; Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.
  • Sævik M; Department of Anesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway.
  • Heien AR; Joint Biotechnology Laboratory, Department of Chemistry, University of Turku, Turku, Finland.
  • Tellevik MG; Joint Biotechnology Laboratory, Department of Chemistry, University of Turku, Turku, Finland.
  • Barry E; Division for Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
  • Langeland N; Division for Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
  • Sommerfelt H; Division for Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
  • Hanevik K; Norwegian National Advisory Unit on Tropical Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
PLoS Negl Trop Dis ; 13(10): e0007823, 2019 10.
Article en En | MEDLINE | ID: mdl-31665141
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Vacunas contra Escherichia coli / Enterotoxinas / Infecciones por Escherichia coli / Escherichia coli Enterotoxigénica Límite: Adult / Female / Humans / Male Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2019 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Vacunas contra Escherichia coli / Enterotoxinas / Infecciones por Escherichia coli / Escherichia coli Enterotoxigénica Límite: Adult / Female / Humans / Male Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2019 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Estados Unidos