Different distribution of DNA polymerases alpha and beta in bone marrow and peripheral blood from human leukemia.
Med Oncol Tumor Pharmacother
; 5(3): 181-6, 1988.
Article
en En
| MEDLINE
| ID: mdl-3166085
An activity gel method was used to analyze the catalytic polypeptides of polymerases alpha and beta in human acute myeloblastic and lymphoblastic leukemia. A 175 kDa alpha-polymerase was found in 85% of bone marrow and in 57% of peripheral blood samples. At variance, a 40 kDa beta-polymerase was found in 94% of peripheral blood and only in 12% of bone marrow samples. No difference in the pattern of polymerase expression was found according to the type of leukemia and the disease status. The role of these enzymes in leukemia and their implications in drug sensitivity are discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Médula Ósea
/
Leucemia Mieloide Aguda
/
Leucemia Linfoide
/
ADN Polimerasa I
/
ADN Polimerasa II
Límite:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Med Oncol Tumor Pharmacother
Año:
1988
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Reino Unido