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A comparison of genotyping tool in Treponema pallidum: Review and meta-analysis.
Fu, Bo; Li, Huahua; Zhao, Yulong; Li, Wei; Zhao, Feijun; Yu, Jian; Liu, Shuangquan; Zhao, Tie; Xiao, Yongjian; Li, Changqing; Cao, Longgu; Zeng, Tiebing.
Afiliación
  • Fu B; Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang, Hunan, China.
  • Li H; Department of Clinical Laboratory, The First Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
  • Zhao Y; Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang, Hunan, China.
  • Li W; Department of Clinical Laboratory, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
  • Zhao F; Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang, Hunan, China.
  • Yu J; Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang, Hunan, China.
  • Liu S; Department of Clinical Laboratory, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
  • Zhao T; Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang, Hunan, China.
  • Xiao Y; Clinical Laboratory, The Second Affiliated Hospital of University of South China, Hengyang, Hunan, China.
  • Li C; The Hunan Province Innovative Training Base for Postgraduates, University of South China and Nanyue Biopharmaceutical Co. Ltd., Hengyang, Hunan, China.
  • Cao L; Department of Medical Examination, Xiangnan University, Chenzhou, Hunan, China. Electronic address: 158326766@qq.com.
  • Zeng T; Institute of Pathogenic Biology, Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, University of South China, Hengyang, Hunan, China. Electronic address: nhdxztb@126.com.
Infect Genet Evol ; 78: 104049, 2020 03.
Article en En | MEDLINE | ID: mdl-31655225
BACKGROUND: To decipher the molecular epidemiology of the Treponema pallidum subspecies, pallidum, researchers have developed different molecular typing schemes which identify strains type from clinical specimens. However, the results of these studies show remarkable diversity. METHODS: We searched for literature in PubMed, MEDLINE, Web of Sciences, and OVID from January 1998 to January 2019, in order to compare the efficiency of typing schemes using published evidence for systematic reviews and meta-analyses. RESULTS: From the 43 studies included, the overall typing efficiency of Treponema pallidum was 71.4% (95% CI: 63.2-78.9%). Subgroup analyses indicated that the typing efficiency of CDC-typing (CDCT, 68.2%, 95% CI: 53.6-81.2%) was worse than those of enhanced CDC-typing (ECDCT, 72.3%, 95% CI: 60-83.1%), CDC-rspA (81.6%, 95% CI: 76.1-86.6%), multi-locus sequence typing (MLST, 67.1%, 95% CI: 61.1-72.7), and sequencing-based molecular typing (SBMT, 71.6%, 95% CI: 50-89.2%). A limitation of this review is that the studies included employed different criteria to collect and investigate samples of Treponema pallidum, which could contribute to heterogeneity. CONCLUSIONS: This analysis suggests that CDCT is an inferior scheme in molecular typing, the discriminatory power was very similar for ECDCT and SBMT. Other factors contributing to the heterogeneity between typing studies warrants further study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Treponema pallidum / Sífilis / Técnicas de Tipificación Bacteriana Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Infect Genet Evol Asunto de la revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Treponema pallidum / Sífilis / Técnicas de Tipificación Bacteriana Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Infect Genet Evol Asunto de la revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos