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Health Care Utilization and End-of-Life Care Outcomes for Patients With Decompensated Cirrhosis Based on Transplant Candidacy.
Ufere, Nneka N; Halford, Jennifer L; Caldwell, Joshua; Jang, Min Young; Bhatt, Sunil; Donlan, John; Ho, Janet; Jackson, Vicki; Chung, Raymond T; El-Jawahri, Areej.
Afiliación
  • Ufere NN; Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: nufere@partners.org.
  • Halford JL; Harvard Medical School, Boston, Massachusetts, USA.
  • Caldwell J; Harvard Medical School, Boston, Massachusetts, USA.
  • Jang MY; Harvard Medical School, Boston, Massachusetts, USA.
  • Bhatt S; Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Donlan J; Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Ho J; Division of Palliative Care and Geriatric Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Jackson V; Division of Palliative Care and Geriatric Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Chung RT; Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • El-Jawahri A; Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
J Pain Symptom Manage ; 59(3): 590-598, 2020 03.
Article en En | MEDLINE | ID: mdl-31655192
CONTEXT: Patients with decompensated cirrhosis have high rates of health care utilization at end of life (EOL). However, the impact of transplant candidacy on intensity of EOL care is currently unknown. OBJECTIVES: To assess the relationship between transplant candidacy and intensity of EOL care in the last year of life in an ambulatory cohort of patients with decompensated cirrhosis. METHODS: We performed a retrospective analysis of 230 patients with decompensated cirrhosis who were evaluated for liver transplantation in a large health care system between 1/1/2010 and 12/31/2017 and died by 6/20/2018. We compared health care utilization in the last year of life and EOL care outcomes between transplant-listed (n = 133) and nonlisted (n = 97) patients. We examined predictors of palliative and hospice care utilization using multivariate logistic regression. RESULTS: During the last year of life, patients had a median of three hospitalizations (IQR 2-5) and spent a median of 31 days (IQR 16-49) in the hospital. In all, 80% of patients died in the hospital, with 70% dying in the intensive care unit. The majority (70.0%) received a life-sustaining procedure (mechanical ventilation, renal replacement therapy, or cardiopulmonary resuscitation) during their terminal hospitalization, which did not differ between transplant-listed and nonlisted patients (74.4% vs. 63.9%, P = 0.09). Transplant-listed patients had lower odds of receiving specialty palliative care (odds ratio 0.43, P = 0.005). Patients with hepatocellular carcinoma had higher odds of receiving hospice care (odds ratio 2.03, P = 0.049). CONCLUSION: Patients with decompensated cirrhosis had intensive health care utilization during their last year of life regardless of transplant candidacy. Further work is needed to optimize their EOL care, particularly for patients who are ineligible for transplantation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuidado Terminal / Várices Esofágicas y Gástricas / Cuidados Paliativos al Final de la Vida / Carcinoma Hepatocelular / Enfermedad Hepática en Estado Terminal / Neoplasias Hepáticas Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Implementation_research Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Pain Symptom Manage Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA / TERAPEUTICA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuidado Terminal / Várices Esofágicas y Gástricas / Cuidados Paliativos al Final de la Vida / Carcinoma Hepatocelular / Enfermedad Hepática en Estado Terminal / Neoplasias Hepáticas Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Implementation_research Límite: Female / Humans / Male / Middle aged Idioma: En Revista: J Pain Symptom Manage Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA / TERAPEUTICA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos