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Management of Acute Cholecystitis during Neoadjuvant Therapy in Patients with Pancreatic Adenocarcinoma.
Jariwalla, Neil R; Khan, Abdul H; Dua, Kulwinder; Christians, Kathleen K; Clarke, Callisia N; Aldakkak, Mohammed; George, Ben; Tutton, Sean; Rilling, William; Erickson, Beth; Evans, Douglas B; Tsai, Susan.
Afiliación
  • Jariwalla NR; Pancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Khan AH; Pancreatic Cancer Program, Department of Gastroenterology, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Dua K; Pancreatic Cancer Program, Department of Gastroenterology, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Christians KK; Pancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Clarke CN; Pancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Aldakkak M; Pancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • George B; Pancreatic Cancer Program, Department of Hematology-Oncology, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Tutton S; Pancreatic Cancer Program, Department of Radiology, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Rilling W; Pancreatic Cancer Program, Department of Radiology, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Erickson B; Pancreatic Cancer Program, Department of Radiation Oncology, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Evans DB; Pancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, Milwaukee, WI, USA.
  • Tsai S; Pancreatic Cancer Program, Department of Surgery, The Medical College of Wisconsin, Milwaukee, WI, USA. stsai@mcw.edu.
Ann Surg Oncol ; 26(13): 4515-4521, 2019 Dec.
Article en En | MEDLINE | ID: mdl-31641946
BACKGROUND: Patients with localized pancreatic cancer (PC) can develop acute cholecystitis during neoadjuvant therapy; optimal management remains undefined. METHODS: Consecutive patients with localized PC who had indwelling biliary stents and received neoadjuvant therapy were reviewed. Time from stent placement to the development of acute cholecystitis was calculated. Patients were categorized as having surgical versus nonoperative management of cholecystitis. Time to PC resection was defined as the time from the start of treatment to pancreatic resection. RESULTS: Of the 283 patients with indwelling biliary stents, acute cholecystitis occurred in 17 (6%) patients. The median time from the date of stent placement to the development of cholecystitis was 2.3 months [interquartile range (IQR) 4.6 months]. Acute cholecystitis was managed with cholecystostomy tube placement in 15 (88%) patients and cholecystectomy in 2 (12%). In total, 189 (67%) of the 283 patients completed all intended neoadjuvant therapy and surgery; 10 (59%) of the 17 patients with cholecystitis (10 of 15 managed with a cholecystostomy tube and 0 of 2 managed with cholecystectomy) and 179 (67%) of the 266 patients without cholecystitis (p = 0.47). The median time to PC resection was 3.2 months for the 179 patients without cholecystitis and 3.6 months for the 10 patients with cholecystitis (p = 1.00). CONCLUSIONS: Acute cholecystitis occurred in 6% of patients with indwelling biliary stents during neoadjuvant therapy. Management with a cholecystostomy tube did not delay the completion of neoadjuvant therapy and surgery and should be considered the optimal management of this complication.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Colecistitis Aguda Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Adenocarcinoma / Colecistitis Aguda Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos