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Biological evaluation and molecular dynamics simulation of water-soluble fullerene derivative C60[C(COOH)2]3.
Gaponenko, Ivan N; Ageev, Sergei V; Iurev, Gleb O; Shemchuk, Olga S; Meshcheriakov, Anatolii A; Petrov, Andrey V; Solovtsova, Irina L; Vasina, Lubov V; Tennikova, Tatiana B; Murin, Igor V; Semenov, Konstantin N; Sharoyko, Vladimir V.
Afiliación
  • Gaponenko IN; Pavlov First Saint Petersburg State Medical University, L'va Tolstogo str. 6-8, Saint Petersburg 197022, Russia.
  • Ageev SV; Institute of Chemistry, Saint Petersburg State University, Universitetskii pr. 26, Saint Petersburg 198504, Russia.
  • Iurev GO; Pavlov First Saint Petersburg State Medical University, L'va Tolstogo str. 6-8, Saint Petersburg 197022, Russia; Almazov National Medical Research Centre, Akkuratova str. 2, Saint Petersburg 197341, Russia.
  • Shemchuk OS; Institute of Chemistry, Saint Petersburg State University, Universitetskii pr. 26, Saint Petersburg 198504, Russia.
  • Meshcheriakov AA; Institute of Chemistry, Saint Petersburg State University, Universitetskii pr. 26, Saint Petersburg 198504, Russia.
  • Petrov AV; Institute of Chemistry, Saint Petersburg State University, Universitetskii pr. 26, Saint Petersburg 198504, Russia.
  • Solovtsova IL; Pavlov First Saint Petersburg State Medical University, L'va Tolstogo str. 6-8, Saint Petersburg 197022, Russia.
  • Vasina LV; Pavlov First Saint Petersburg State Medical University, L'va Tolstogo str. 6-8, Saint Petersburg 197022, Russia; Almazov National Medical Research Centre, Akkuratova str. 2, Saint Petersburg 197341, Russia.
  • Tennikova TB; Institute of Chemistry, Saint Petersburg State University, Universitetskii pr. 26, Saint Petersburg 198504, Russia.
  • Murin IV; Institute of Chemistry, Saint Petersburg State University, Universitetskii pr. 26, Saint Petersburg 198504, Russia.
  • Semenov KN; Pavlov First Saint Petersburg State Medical University, L'va Tolstogo str. 6-8, Saint Petersburg 197022, Russia; Institute of Chemistry, Saint Petersburg State University, Universitetskii pr. 26, Saint Petersburg 198504, Russia; Almazov National Medical Research Centre, Akkuratova str. 2, Saint Pete
  • Sharoyko VV; Institute of Chemistry, Saint Petersburg State University, Universitetskii pr. 26, Saint Petersburg 198504, Russia; Pavlov First Saint Petersburg State Medical University, L'va Tolstogo str. 6-8, Saint Petersburg 197022, Russia.
Toxicol In Vitro ; 62: 104683, 2020 Feb.
Article en En | MEDLINE | ID: mdl-31639450
One of the most studied fullerene members, C60, has a potential of application in various fields of biomedicine including reactive oxygen species (ROS) scavenging activity, inhibiting of tumours development, inactivating of viruses and bacteria, as well as elaboration of diagnostic and targeted drug delivery tools. However, the hydrophobicity of this molecule impedes its practical use, therefore the actuality of the research devoted to functionalisation of fullerenes leading to amphiphilic derivatives remains important. In this work, the water-soluble carboxylated fullerene derivative C60[C(COOH)2]3 was studied. Extensive biomedical investigation of this compound, namely, the binding with human serum albumin (HSA), radical scavenging activity in the reaction with diphenylpicrylhydrazyl (DPPH) radical, photodynamic properties, cytotoxicity in human embryonic kidney (HEK293) cell line, erythrocytes' haemolysis, platelet aggregation, and genotoxicity in human peripheral mononuclear cells (PBMC) was conducted. Moreover, the dynamic and structural characteristics of C60[C(COOH)2]3-H2O binary system were obtained using molecular dynamic (MD) method, and size distribution of C60[C(COOH)2]3 associates was measured.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fulerenos Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Toxicol In Vitro Asunto de la revista: TOXICOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fulerenos Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Toxicol In Vitro Asunto de la revista: TOXICOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido