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Selected nucleos(t)ide-based prescribed drugs and their multi-target activity.
Pastuch-Gawolek, Gabriela; Gillner, Danuta; Król, Ewelina; Walczak, Krzysztof; Wandzik, Ilona.
Afiliación
  • Pastuch-Gawolek G; Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Krzywoustego 4, 44-100, Gliwice, Poland; Biotechnology Centre, Silesian University of Technology, Krzywoustego 8, 44-100, Gliwice, Poland.
  • Gillner D; Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Krzywoustego 4, 44-100, Gliwice, Poland; Biotechnology Centre, Silesian University of Technology, Krzywoustego 8, 44-100, Gliwice, Poland.
  • Król E; Department of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307, Gdansk, Poland.
  • Walczak K; Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Krzywoustego 4, 44-100, Gliwice, Poland.
  • Wandzik I; Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Krzywoustego 4, 44-100, Gliwice, Poland; Biotechnology Centre, Silesian University of Technology, Krzywoustego 8, 44-100, Gliwice, Poland. Electronic address: Ilona.Wandz
Eur J Pharmacol ; 865: 172747, 2019 Dec 15.
Article en En | MEDLINE | ID: mdl-31634460
Nucleos(t)ide analogues play pivotal roles as antiviral, cytotoxic or immunosuppressive agents. Here, we review recent reports of nucleoside analogues that exhibit broad-spectrum activity towards multiple life-threatening RNA and DNA viruses. We also present a discussion about nucleoside antimetabolites-approved antineoplastic agents-that have recently been shown to have antiviral and/or antibacterial activity. The approved drugs and drug combinations, as well as recently identified candidates for investigation and/or experimentation, are discussed. Several examples of repurposed drugs that have already been approved for use are presented. This strategy can be crucial for the first-line treatment of acute infections or coinfections and for the management of drug-resistant strains.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prescripciones de Medicamentos / Terapia Molecular Dirigida / Nucleósidos / Nucleótidos Límite: Humans Idioma: En Revista: Eur J Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prescripciones de Medicamentos / Terapia Molecular Dirigida / Nucleósidos / Nucleótidos Límite: Humans Idioma: En Revista: Eur J Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Países Bajos