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The potential therapeutic effect of NG-hydroxy-nor-L-arginine in 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats.
Avtandilyan, Nikolay; Javrushyan, Hayarpi; Mamikonyan, Anahit; Grigoryan, Anna; Trchounian, Armen.
Afiliación
  • Avtandilyan N; Laboratory of Biochemistry, Research Institute of Biology, Faculty of Biology, Yerevan State University, Yerevan, Armenia; Department of Biochemistry, Microbiology and Biotechnology, Faculty of Biology, Yerevan State University, Yerevan, Armenia. Electronic address: nv.avtandilyan@ysu.am.
  • Javrushyan H; Laboratory of Biochemistry, Research Institute of Biology, Faculty of Biology, Yerevan State University, Yerevan, Armenia. Electronic address: hg.javrushyan@ysu.am.
  • Mamikonyan A; Department of Biochemistry, Microbiology and Biotechnology, Faculty of Biology, Yerevan State University, Yerevan, Armenia. Electronic address: anahit.mamikonyan@ysu.am.
  • Grigoryan A; Department of Zoology, Faculty of Biology, Yerevan State University, Yerevan, Armenia. Electronic address: annagrigoryan@ysu.am.
  • Trchounian A; Department of Biochemistry, Microbiology and Biotechnology, Faculty of Biology, Yerevan State University, Yerevan, Armenia. Electronic address: Trchounian@ysu.am.
Exp Mol Pathol ; 111: 104316, 2019 12.
Article en En | MEDLINE | ID: mdl-31629728
Advances in our understanding of the metabolism and molecular functions of arginine and their alterations in cancer have led to resurgence in the interest of targeting arginine catabolism as an anticancer strategy. Therefore, arginase inhibitors have been proposed as a way to treat cancer. In this study, the anti-tumor potential of the arginase inhibition by NG-hydroxy-nor-L-arginine (nor-NOHA) (3 mg/kg/day, i.p.), administered for 5 weeks (parallel tumors development, every 3th day) against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis in rats has been investigated. Treatment by nor-NOHA has obvious inhibition effects on development of carcinogenesis in rats was shown. That was seen in downregulation of rats' tumors size and number, mortality rate, in stopped alteration of tissue histopathology, in decrease of polyamines, NO and MDA (malondialdeide) concentrations (in blood). Results have shown arginase and NO-synthase can cooperate to restrain quantities of polyamines and NO for cancer progression. The results obtained can serve as a base to use this model for determination of productive, noncytotoxic antitumor and immune modulating concentration of anticancer agents. Perspectives of targeting arginase and NOS in cancer management can ground application in clinical medicine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arginina / Neoplasias de la Mama / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Exp Mol Pathol Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arginina / Neoplasias de la Mama / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Exp Mol Pathol Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos