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Effects of Peptide YY on the Hypothalamic-Pituitary-Gonadal Axis in Healthy Men.
Izzi-Engbeaya, Chioma; Jones, Sophie; Crustna, Yoshibye; Machenahalli, Pratibha C; Papadopoulou, Deborah; Modi, Manish; Panayi, Christos; Starikova, Jessica; Eng, Pei Chia; Phylactou, Maria; Mills, Edouard; Yang, Lisa; Ratnasabapathy, Risheka; Sykes, Mark; Plumptre, Isabella; Coumbe, Ben; Wing, Victoria; Pacuszka, Ewa; Bech, Paul; Minnion, James; Tharakan, George; Tan, Tricia; Veldhuis, Johannes; Abbara, Ali; Comninos, Alexander N; Dhillo, Waljit S.
Afiliación
  • Izzi-Engbeaya C; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Jones S; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Crustna Y; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Machenahalli PC; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Papadopoulou D; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Modi M; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Panayi C; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Starikova J; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Eng PC; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Phylactou M; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Mills E; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Yang L; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Ratnasabapathy R; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Sykes M; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Plumptre I; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Coumbe B; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Wing V; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Pacuszka E; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Bech P; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Minnion J; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Tharakan G; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Tan T; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Veldhuis J; Department of Internal Medicine, Mayo Clinic, Minnesota.
  • Abbara A; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Comninos AN; Section of Endocrinology and Investigative Medicine, Department of Medicine, Imperial College London, London, UK.
  • Dhillo WS; Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK.
J Clin Endocrinol Metab ; 105(3)2020 03 01.
Article en En | MEDLINE | ID: mdl-31628465
CONTEXT: Central and peripheral administration of peptide YY (PYY) has potent anorectic effects, and PYY analogs are under development as antiobesity treatments. Recent animal data suggest PYY may also influence the reproductive axis; however the effects of PYY on the human reproductive system are unknown. OBJECTIVE: To investigate the effects of PYY administration on the reproductive axis in healthy young men. DESIGN: Single-blind, randomized, placebo-controlled crossover study. SETTING: Clinical Research Facility, Imperial College Healthcare NHS Trust. PARTICIPANTS: Eighteen healthy eugonadal men (mean age 24.1 ± 0.9 years, mean body mass index 22.2 ± 0.4 kg/m2). INTERVENTION: Eight-hour intravenous infusion of 0.4 pmol/kg/min PYY3-36 or rate-matched vehicle infusion. MAIN OUTCOME MEASURES: Number of luteinizing hormone (LH) pulses, LH, follicle stimulating hormone (FSH), and testosterone levels. RESULTS: The number of LH pulses (mean number of LH pulses/8 hours: PYY 4.4 ± 0.3 vs vehicle 4.4 ± 0.4, P > .99), LH area under the curve (AUC) (PYY 1503 ± 79 IU.min/L vs vehicle 1574 ± 86 IU.min/L, P = .36), FSH AUC (PYY 1158 ± 513 IU.min/L vs vehicle 1199 ± 476 IU.min/L, P = .49) and testosterone AUC (PYY 10 485 ± 684 IU.min/L vs vehicle 11 133 ± 803 IU.min/L, P = .24) were similar during PYY and vehicle infusions. CONCLUSIONS: Acute intravenous infusion of 0.4 pmol/kg/min PYY does not affect the reproductive axis in healthy men.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testosterona / Hormona Luteinizante / Biomarcadores / Péptido YY / Hormona Folículo Estimulante / Sistema Hipotálamo-Hipofisario Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Humans / Male Idioma: En Revista: J Clin Endocrinol Metab Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testosterona / Hormona Luteinizante / Biomarcadores / Péptido YY / Hormona Folículo Estimulante / Sistema Hipotálamo-Hipofisario Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Humans / Male Idioma: En Revista: J Clin Endocrinol Metab Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos