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[Results of a clinical study of a new anxiolytic, a blocker of central cholecystokinin receptors]. / Rezul'taty klinicheskogo issledovaniia novogo anksiolitika, blokatora tsentral'nykh kholetsistokininovykh retseptorov.
Neznamov, G G; Dorofeeva, O A; Metlina, M V; Syunyakov, T S; Minaev, S V; Ivashkina, N Yu; Martyanov, V A; Seredenin, S B.
Afiliación
  • Neznamov GG; Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Dorofeeva OA; Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Metlina MV; Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Syunyakov TS; Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Minaev SV; Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Ivashkina NY; Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Martyanov VA; Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Seredenin SB; Zakusov Research Institute of Pharmacology, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova ; 119(8): 53-60, 2019.
Article en Ru | MEDLINE | ID: mdl-31626171
AIM: To evaluate anxiolytic action of GB-115, a low-affinity blocker of central cholecystokinin receptors, used in tablets in a dose of 1 mg for the treatment of patients with anxiety disorders in order to determine effective dose, safety, tolerability and efficacy in clinical settings. MATERIAL AND METHODS: The study included 31 patients (22 women, 9 men) diagnosed with generalized anxiety disorder (GAD, F41.1 according to ICD-10), aged from 22 to 53 years. The duration of treatment was 21 days. The Hamilton Anxiety Rating scale, Psychopathologic symptoms severity evaluation scale (PSSES), Spilberger State-Anxiety Inventory, Multidimensional Fatigue Inventory (MFI), Clinical Global Impression scale (CGI), computerized battery for evaluation of cognitive functions ('NS-Psychotest') were used. RESULTS AND CONCLUSION: The effective dose of GB-115 was determined at 6 mg per day. Drug action is characterized by fast onset of anxiolytic effect with stimulating properties and beneficial effect on sleep disturbances and autonomic symptoms. GB-115 treatment was associated with favorable changes in attention parameters, reaction time and overall performance. In contrast to first-line drugs for GAD treatment (SSRIs and SNRIs), GB-115 does not induce initial overactivation, anxiety and sleep disturbances. GB-115 is safe and has a good tolerability.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Ansiedad / Ansiolíticos / Receptores de Colecistoquinina Límite: Adult / Female / Humans / Male / Middle aged Idioma: Ru Revista: Zh Nevrol Psikhiatr Im S S Korsakova Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Ansiedad / Ansiolíticos / Receptores de Colecistoquinina Límite: Adult / Female / Humans / Male / Middle aged Idioma: Ru Revista: Zh Nevrol Psikhiatr Im S S Korsakova Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Rusia