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Determining nicotine-related behavior changes in juvenile female rats through long-term maternal nicotine exposure.
Jang, Minji; Jung, Taesub; Kim, Woonhee; Kim, Inyong; Jeong, Yoonhwa; Noh, Jihyun.
Afiliación
  • Jang M; Department of Science Education, College of Education, Dankook University, Yongin-si, Gyeonggi-do.
  • Jung T; Department of Science Education, College of Education, Dankook University, Yongin-si, Gyeonggi-do.
  • Kim W; Department of Science Education, College of Education, Dankook University, Yongin-si, Gyeonggi-do.
  • Kim I; Department of Food Science and Nutrition and Research Center for Industrialization of Natural Nutraceuticals, Dankook University, Cheonan-si, Chungnam, Republic of Korea.
  • Jeong Y; Department of Food Science and Nutrition and Research Center for Industrialization of Natural Nutraceuticals, Dankook University, Cheonan-si, Chungnam, Republic of Korea.
  • Noh J; Department of Science Education, College of Education, Dankook University, Yongin-si, Gyeonggi-do.
Behav Pharmacol ; 31(1): 34-44, 2020 02.
Article en En | MEDLINE | ID: mdl-31625971
Nicotine replacement therapy (NRT) has been developed as a drug therapy for smoking cessation and has been considered a safe alternative to smoking during pregnancy. However, the effects of long-term nicotine exposure via NRT on the fetus are still being debated. Here, we determined the effects of long-term maternal nicotine exposure in gestation and lactation on nicotine-related behavior and drug vulnerability in dams and offspring rats. To expose long-term nicotine, on gestation day 14, pregnant rats were implanted with osmotic minipumps releasing nicotine tartrate (6 mg/kg/day, subcutaneously, equivalent to 2 mg nicotine-freebase) for 28 days. The concentration of cotinine in blood was 373.0 ± 109.0 ng/ml in dams and 12.50 ± 1.19 ng/ml in offspring rats. In dams, we found no significant differences in anxiety-like behaviors and various maternal behaviors such as touching, sniffing, pup licking, laying on pups, and retrieval between saline- and nicotine-exposed groups. Adolescent offspring female rats showed no significant differences in anxiety-like behavior and forced alcohol consumption between saline- and nicotine-exposed groups. Nicotine-exposed offspring rats showed more increased nicotine aversion than saline-exposed groups, but the effect was disturbed in the forced alcohol consumption condition on the first day of the nicotine consumption test. Taken together, these results suggest that, in the last gestation and lactation period corresponding to the second and third trimester of human pregnancy, long-term maternal nicotine exposure has a minor effect on dam and female offspring health and does not involve serious pathological changes in rat offspring, despite the presence of nicotine in their blood.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dispositivos para Dejar de Fumar Tabaco / Nicotina Límite: Animals / Pregnancy Idioma: En Revista: Behav Pharmacol Asunto de la revista: CIENCIAS DO COMPORTAMENTO / FARMACOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dispositivos para Dejar de Fumar Tabaco / Nicotina Límite: Animals / Pregnancy Idioma: En Revista: Behav Pharmacol Asunto de la revista: CIENCIAS DO COMPORTAMENTO / FARMACOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido