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Beta1- and Beta2-Adrenoceptors Expression Patterns in Human Non-small Cell Lung Cancer: Relationship with Cancer Histology.
Coelho, Marisa; Imperatori, Andrea; Chiaravalli, Anna Maria; Franzi, Francesca; Castiglioni, Massimo; Rasini, Emanuela; Luini, Alessandra; Legnaro, Massimiliano; Marino, Franca; Ribeiro, Laura; Cosentino, Marco.
Afiliación
  • Coelho M; Department of Biomedicine, Unit of Biochemistry, Faculty of Medicine, University of Porto, Rua Dr. Plácido da Costa, s/n, 4200-450, Porto, Portugal. mcoelho@med.up.pt.
  • Imperatori A; I3S - Instituto de Investigação e Inovação em Saúde, University of Porto, Rua Alfredo Allen, 4200-135, Porto, Portugal. mcoelho@med.up.pt.
  • Chiaravalli AM; Center of Research in Medical Pharmacology, University of Insubria, Via Monte Generoso 71, 21100, Varese, Italy. mcoelho@med.up.pt.
  • Franzi F; Center for Thoracic Surgery, Department of Medicine and Surgery, ASST Sette Laghi, University of Insubria, via Guicciardini 9, 21100, Varese, Italy.
  • Castiglioni M; Unit of Pathology, Department of Medicine and Surgery, ASST Sette Laghi, University of Insubria, via Rossi 9, 21100, Varese, Italy.
  • Rasini E; Unit of Pathology, Department of Medicine and Surgery, ASST Sette Laghi, University of Insubria, via Rossi 9, 21100, Varese, Italy.
  • Luini A; Center for Thoracic Surgery, Department of Medicine and Surgery, ASST Sette Laghi, University of Insubria, via Guicciardini 9, 21100, Varese, Italy.
  • Legnaro M; Center of Research in Medical Pharmacology, University of Insubria, Via Monte Generoso 71, 21100, Varese, Italy.
  • Marino F; Center of Research in Medical Pharmacology, University of Insubria, Via Monte Generoso 71, 21100, Varese, Italy.
  • Ribeiro L; Center of Research in Medical Pharmacology, University of Insubria, Via Monte Generoso 71, 21100, Varese, Italy.
  • Cosentino M; Center of Research in Medical Pharmacology, University of Insubria, Via Monte Generoso 71, 21100, Varese, Italy.
J Neuroimmune Pharmacol ; 14(4): 697-708, 2019 12.
Article en En | MEDLINE | ID: mdl-31620969
Assessment of Beta-AR protein expression on tumour tissues might be a plausible strategy to select cancer patients who can benefit from Beta-blockers therapy. The aim of this study is to evaluate the differences between resected tissue specimens from primary lung cancer (adenocarcinoma (ADC) and squamous cell carcinoma (SCC)) in terms of expression pattern of Beta1- and Beta2-AR in both tumour and adjacent surrounding non-tumour tissue. This retrospective study was based on the analysis of 80 patients with histologically confirmed diagnosis of primary Non-Small Cell Lung Cancer (NSCLC) who received surgical treatment. The cases were carefully selected in order to obtain the most homogeneous sample in terms of histologic subtype (40 ADCs and 40 SCCs) and clinical stage (10 each). Beta1- and Beta2-AR expression was determined by immunohistochemistry and the staining evaluated by semi-quantitative scoring using the H-score method. In our NSCLC series, Beta1- and Beta2-AR are differentially expressed. Beta1-AR expression is present at low levels in both SCC and ADC. Likewise, when compared with the matched surrounding non-tumour tissues, Beta1-AR expression level was significantly lower in both histologic subtypes. Conversely, Beta2-AR is highly expressed in both histologic subtypes, but clearly highly expressed in ADC when compared with SCC and with their matched surrounding non-tumour tissue. Overall, this clinicopathological study highlights the differential expression of Beta1- and Beta2-AR in ADC and SCC. Repurposing non-selective Beta-blockers in oncologic setting might be a suitable therapeutic strategy for lung ADC. Graphical abstract.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Enzimológica de la Expresión Génica / Receptores Adrenérgicos beta 2 / Receptores Adrenérgicos beta 1 / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Observational_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neuroimmune Pharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA / NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Enzimológica de la Expresión Génica / Receptores Adrenérgicos beta 2 / Receptores Adrenérgicos beta 1 / Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Tipo de estudio: Observational_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neuroimmune Pharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA / NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Estados Unidos