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A network of trans-cortical capillaries as mainstay for blood circulation in long bones.
Grüneboom, Anika; Hawwari, Ibrahim; Weidner, Daniela; Culemann, Stephan; Müller, Sylvia; Henneberg, Sophie; Brenzel, Alexandra; Merz, Simon; Bornemann, Lea; Zec, Kristina; Wuelling, Manuela; Kling, Lasse; Hasenberg, Mike; Voortmann, Sylvia; Lang, Stefanie; Baum, Wolfgang; Ohs, Alexandra; Kraff, Oliver; Quick, Harald H; Jäger, Marcus; Landgraeber, Stefan; Dudda, Marcel; Danuser, Renzo; Stein, Jens V; Rohde, Manfred; Gelse, Kolja; Garbe, Annette I; Adamczyk, Alexandra; Westendorf, Astrid M; Hoffmann, Daniel; Christiansen, Silke; Engel, Daniel Robert; Vortkamp, Andrea; Krönke, Gerhard; Herrmann, Martin; Kamradt, Thomas; Schett, Georg; Hasenberg, Anja; Gunzer, Matthias.
Afiliación
  • Grüneboom A; Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Hawwari I; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
  • Weidner D; Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Culemann S; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
  • Müller S; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
  • Henneberg S; Institute of Immunology, Universitätsklinikum Jena, Jena, Germany.
  • Brenzel A; Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Merz S; Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Bornemann L; Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Zec K; Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Wuelling M; Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Kling L; Department of Developmental Biology, Centre of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.
  • Hasenberg M; Max Planck Institute for the Science of Light, Christiansen Research Group, Erlangen, Germany.
  • Voortmann S; Helmholtz-Zentrum Berlin, Institute for Nanoarchitectures for Energy Conversion, Berlin, Germany.
  • Lang S; Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Baum W; Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Ohs A; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
  • Kraff O; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
  • Quick HH; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
  • Jäger M; Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany.
  • Landgraeber S; Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany.
  • Dudda M; High Field and Hybrid MR Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Danuser R; Department of Orthopaedics and Trauma Surgery, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Stein JV; Department of Orthopaedics and Trauma Surgery, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Rohde M; Department of Orthopaedics and Trauma Surgery, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Gelse K; Theodor Kocher Institute, University of Bern, Bern, Switzerland.
  • Garbe AI; Theodor Kocher Institute, University of Bern, Bern, Switzerland.
  • Adamczyk A; Central Facility for Microscopy, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Westendorf AM; Department of Trauma Surgery, Friedrich Alexander University Erlangen-Nuremberg andUniversitaetsklinikum Erlangen, Erlangen, Germany.
  • Hoffmann D; Osteoimmunology, DFG-Center for Regenerative Therapies Dresden, Center for Molecular and Cellular Bioengineering , Technische Universität Dresden, Cluster of Excellence, Dresden, Germany.
  • Christiansen S; Institute of Medical Microbiology, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Engel DR; Institute of Medical Microbiology, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Vortkamp A; Bioinformatics and Computational Biophysics, Faculty of Biology, University Duisburg-Essen, Essen, Germany.
  • Krönke G; Max Planck Institute for the Science of Light, Christiansen Research Group, Erlangen, Germany.
  • Herrmann M; Helmholtz-Zentrum Berlin, Institute for Nanoarchitectures for Energy Conversion, Berlin, Germany.
  • Kamradt T; Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Schett G; Department of Developmental Biology, Centre of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.
  • Hasenberg A; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
  • Gunzer M; Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitaetsklinikum Erlangen, Erlangen, Germany.
Nat Metab ; 1(2): 236-250, 2019 02.
Article en En | MEDLINE | ID: mdl-31620676
Closed circulatory systems (CCS) underlie the function of vertebrate organs, but in long bones their structure is unclear, although they constitute the exit route for bone marrow (BM) leukocytes. To understand neutrophil emigration from BM, we studied the vascular system of murine long bones. Here we show that hundreds of capillaries originate in BM, cross murine cortical bone perpendicularly along the shaft and connect to the periosteal circulation. Structures similar to these trans-cortical-vessels (TCVs) also exist in human limb bones. TCVs express arterial or venous markers and transport neutrophils. Furthermore, over 80% arterial and 59% venous blood passes through TCVs. Genetic and drug-mediated modulation of osteoclast count and activity leads to substantial changes in TCV numbers. In a murine model of chronic arthritic bone inflammation, new TCVs develop within weeks. Our data indicate that TCVs are a central component of the CCS in long bones and may represent an important route for immune cell export from the BM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flujo Sanguíneo Regional / Huesos / Capilares / Microcirculación Límite: Animals / Humans Idioma: En Revista: Nat Metab Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flujo Sanguíneo Regional / Huesos / Capilares / Microcirculación Límite: Animals / Humans Idioma: En Revista: Nat Metab Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania