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An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium.
Wong, Ting Yat; Radua, Joaquim; Pomarol-Clotet, Edith; Salvador, Raymond; Albajes-Eizagirre, Anton; Solanes, Aleix; Canales-Rodriguez, Erick J; Guerrero-Pedraza, Amalia; Sarro, Salvador; Kircher, Tilo; Nenadic, Igor; Krug, Axel; Grotegerd, Dominik; Dannlowski, Udo; Borgwardt, Stefan; Riecher-Rössler, Anita; Schmidt, Andre; Andreou, Christina; Huber, Christian G; Turner, Jessica; Calhoun, Vince; Jiang, Wenhao; Clark, Sarah; Walton, Esther; Spalletta, Gianfranco; Banaj, Nerisa; Piras, Fabrizio; Ciullo, Valentina; Vecchio, Daniela; Lebedeva, Irina; Tomyshev, Alexander S; Kaleda, Vasily; Klushnik, Tatyana; Filho, Geraldo Busatto; Zanetti, Marcus Vinicius; Serpa, Mauricio Henriques; Penteado Rosa, Pedro Gomes; Hashimoto, Ryota; Fukunaga, Masaki; Richter, Anja; Krämer, Bernd; Gruber, Oliver; Voineskos, Aristotle N; Dickie, Erin W; Tomecek, David; Skoch, Antonin; Spaniel, Filip; Hoschl, Cyril; Bertolino, Alessandro; Bonvino, Aurora.
Afiliación
  • Wong TY; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.
  • Radua J; Department of Psychiatry, Brain and Behavioral Laboratory, University of Pennsylvania, Philadelphia, PA, USA.
Psychol Med ; 50(12): 2034-2045, 2020 09.
Article en En | MEDLINE | ID: mdl-31615588
BACKGROUND: Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample. METHOD: To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls. RESULTS: The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression. CONCLUSION: These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Psicología del Esquizofrénico / Agresión / Adelgazamiento de la Corteza Cerebral Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychol Med Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Psicología del Esquizofrénico / Agresión / Adelgazamiento de la Corteza Cerebral Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychol Med Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido