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Characterization of biological variation of peripheral blood immune cytome in an Indian cohort.
Kanodia, Parna; Kaur, Gurvinder; Coshic, Poonam; Chatterjee, Kabita; Neeman, Teresa; George, Anna; Rath, Satyajit; Bal, Vineeta; Prabhu, Savit B.
Afiliación
  • Kanodia P; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
  • Kaur G; Laboratory Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
  • Coshic P; Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Chatterjee K; Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Neeman T; Department of Statistics, Australian National University, ACT, Canberra, Australia.
  • George A; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
  • Rath S; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India. satyajit@nii.ac.in.
  • Bal V; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
  • Prabhu SB; National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India.
Sci Rep ; 9(1): 14735, 2019 10 14.
Article en En | MEDLINE | ID: mdl-31611580
Immune parameters show characteristic normal baseline levels and variance in the population. We characterised the degree of inter-individual and within-individual variation over one-year time period in 33 immune cell subsets by flow cytometry in peripheral blood mononuclear cells from 43 healthy young adult volunteers. Our analysis revealed that immune subsets that showed low variability between individuals also showed low short-term fluctuations within-individuals, as well as concordance in siblings. However, when baseline levels and degree of fluctuation were considered together, individuals failed to cluster into discreet groups. Together, the data reveal complex inter-relationships between immune subsets in individuals, and provide insights into the observed heterogeneity between individuals and between multiple immune subsets.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucocitos Mononucleares Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucocitos Mononucleares Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido