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Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial.
Pose, Elisa; Napoleone, Laura; Amin, Ahmed; Campion, Daniela; Jimenez, César; Piano, Salvatore; Roux, Olivier; Uschner, Frank Erhard; de Wit, Koos; Zaccherini, Giacomo; Alessandria, Carlo; Angeli, Paolo; Bernardi, Mauro; Beuers, Ulrich; Caraceni, Paolo; Durand, François; Mookerjee, Rajeshwar P; Trebicka, Jonel; Vargas, Victor; Andrade, Raúl J; Carol, Marta; Pich, Judit; Ferrero, Juan; Domenech, Gema; Llopis, Marta; Torres, Ferran; Kamath, Patrick S; Abraldes, Juan G; Solà, Elsa; Ginès, Pere.
Afiliación
  • Pose E; Institut D'investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEReHD), Barcelona, Spain; Liver Unit, Hospital Clínic De Barcelona, School of Medicine and Health Sciences University of Barcelona, Barcelona, Spain
  • Napoleone L; Institut D'investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEReHD), Barcelona, Spain; Liver Unit, Hospital Clínic De Barcelona, School of Medicine and Health Sciences University of Barcelona, Barcelona, Spain
  • Amin A; Institute of Liver and Digestive Health, University College London, London, UK.
  • Campion D; Division of Gastroenterology and Hepatology, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
  • Jimenez C; Liver Unit, Hospital Vall d'Hebron and Vall d'Hebron Research Unit (VHIR), Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEReHD), Barcelona, Spain.
  • Piano S; Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine-DIMED, University of Padova, Padova, Italy.
  • Roux O; Hepatology and Liver Intensive Care Unit, Hospital Beaujon, APHP, Clichy, France.
  • Uschner FE; Department of Internal Medicine I, University of Bonn, Bonn, Germany; Department of Internal Medicine I, Goethe University Frankfurt, Frankfurt, Germany.
  • de Wit K; Department of Gastroenterology and Hepatology, University of Amsterdam, Academic Medical Center, University of Amsterdam, Netherlands.
  • Zaccherini G; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Alessandria C; Division of Gastroenterology and Hepatology, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
  • Angeli P; Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine-DIMED, University of Padova, Padova, Italy.
  • Bernardi M; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Beuers U; Department of Gastroenterology and Hepatology, University of Amsterdam, Academic Medical Center, University of Amsterdam, Netherlands.
  • Caraceni P; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Durand F; Hepatology and Liver Intensive Care Unit, Hospital Beaujon, APHP, Clichy, France.
  • Mookerjee RP; Institute of Liver and Digestive Health, University College London, London, UK.
  • Trebicka J; Department of Internal Medicine I, University of Bonn, Bonn, Germany; Department of Internal Medicine I, Goethe University Frankfurt, Frankfurt, Germany; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain; Institute for Bioengineering of Catalonia, Barcelona, Spain.
  • Vargas V; Liver Unit, Hospital Vall d'Hebron and Vall d'Hebron Research Unit (VHIR), Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEReHD), Barcelona, Spain.
  • Andrade RJ; Unidad de Gestión Clínica de Enfermedades Digestivas, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, CIBERehd, Málaga, Spain.
  • Carol M; Institut D'investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEReHD), Barcelona, Spain.
  • Pich J; Clinical Trials Unit, Clinical Pharmacology Department, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Ferrero J; European Clinical Research Infrastructure Network, Paris, France.
  • Domenech G; Biostatistics and Data Management Core Facility, Institut D'Investigacions Biomédiques August Pi i Sunyer, Hospital Clinic Barcelona, Spain.
  • Llopis M; Institut D'investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEReHD), Barcelona, Spain.
  • Torres F; Biostatistics and Data Management Core Facility, Institut D'Investigacions Biomédiques August Pi i Sunyer, Hospital Clinic Barcelona, Spain.
  • Kamath PS; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
  • Abraldes JG; Cirrhosis Care Clinic, Division of Gastroenterology (Liver Unit), University of Alberta, CEGIIR, Edmonton, AB, Canada.
  • Solà E; Institut D'investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEReHD), Barcelona, Spain; Liver Unit, Hospital Clínic De Barcelona, School of Medicine and Health Sciences University of Barcelona, Barcelona, Spain
  • Ginès P; Institut D'investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEReHD), Barcelona, Spain; Liver Unit, Hospital Clínic De Barcelona, School of Medicine and Health Sciences University of Barcelona, Barcelona, Spain
Lancet Gastroenterol Hepatol ; 5(1): 31-41, 2020 01.
Article en En | MEDLINE | ID: mdl-31607677
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Simvastatina / Rifaximina / Hipertensión Portal / Cirrosis Hepática Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Lancet Gastroenterol Hepatol Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Simvastatina / Rifaximina / Hipertensión Portal / Cirrosis Hepática Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Lancet Gastroenterol Hepatol Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos