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Transient Immune Activation in BCG-Vaccinated Infant Rhesus Macaques Is Not Sufficient to Influence Oral Simian Immunodeficiency Virus Infection.
Wood, Matthew P; Wood, Lianna F; Templeton, Megan; Fisher, Bridget; Lippy, Adriana; Jones, Chloe I; Lindestam Arlehamn, Cecilia S; Sette, Alessandro; Fuller, James T; Murapa, Patience; Jaspan, Heather B; Fuller, Deborah H; Sodora, Donald L.
Afiliación
  • Wood MP; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington.
  • Wood LF; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington.
  • Templeton M; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington.
  • Fisher B; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington.
  • Lippy A; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington.
  • Jones CI; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington.
  • Lindestam Arlehamn CS; Division of Vaccine Discovery, La Jolla Institute for Immunology, San Diego.
  • Sette A; Division of Vaccine Discovery, La Jolla Institute for Immunology, San Diego.
  • Fuller JT; Department of Medicine, University of California-San Diego, La Jolla, California.
  • Murapa P; Department of Microbiology, Seattle, Washington; and University of Washington.
  • Jaspan HB; Washington National Primate Research Center, Seattle, Washington.
  • Fuller DH; Department of Microbiology, Seattle, Washington; and University of Washington.
  • Sodora DL; Washington National Primate Research Center, Seattle, Washington.
J Infect Dis ; 222(1): 44-53, 2020 06 16.
Article en En | MEDLINE | ID: mdl-31605528
BCG vaccination has been demonstrated to increase levels of activated CD4+ T cells, thus potentially influencing mother-to-child transmission of human immunodeficiency virus (HIV). To assess the risk of BCG vaccination in HIV infection, we randomly assigned newborn rhesus macaques to receive BCG vaccine or remain unvaccinated and then undergo oral simian immunodeficiency virus (SIV) challenges 3 weeks later. We observed elevated levels of activated peripheral CD4+ T cells (ie, HLA-DR+CD38+CCR5+ CD4+ T cells) by week 3 after vaccination. BCG was also associated with an altered immune gene expression profile, as well as with monocyte activation in both peripheral blood and the draining axillary lymph node, indicating significant BCG vaccine-induced immune activation. Despite these effects, BCG vaccination did not increase the rate of SIV oral transmission or disease progression. Our findings therefore identify patterns of T-cell and monocyte activation that occur after BCG vaccination but do not support the hypothesis that BCG vaccination is a risk factor for postnatal HIV transmission or increased pathogenesis in infants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Inmunodeficiencia Adquirida del Simio / Retrovirus de los Simios / Vacunas contra el SIDAS / Inmunidad Activa / Macaca mulatta Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Infect Dis Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Inmunodeficiencia Adquirida del Simio / Retrovirus de los Simios / Vacunas contra el SIDAS / Inmunidad Activa / Macaca mulatta Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Infect Dis Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos