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Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy.
Fox, Philip R; Keene, Bruce W; Lamb, Kenneth; Schober, Karsten E; Chetboul, Valérie; Luis Fuentes, Virginia; Payne, Jessie Rose; Wess, Gerhard; Hogan, Daniel F; Abbott, Jonathan A; Häggström, Jens; Culshaw, Geoffrey; Fine-Ferreira, Deborah; Cote, Etienne; Trehiou-Sechi, Emilie; Motsinger-Reif, Alison A; Nakamura, Reid K; Singh, Manreet; Ware, Wendy A; Riesen, Sabine C; Borgarelli, Michele; Rush, John E; Vollmar, Andrea; Lesser, Michael B; Van Israel, Nicole; Lee, Pamela Ming-Show; Bulmer, Barret; Santilli, Roberto; Bossbaly, Maribeth J; Quick, Nadine; Bussadori, Claudio; Bright, Janice; Estrada, Amara H; Ohad, Dan G; Del Palacio, Maria Josefa Fernández; Brayley, Jennifer Lunney; Schwartz, Denise S; Gordon, Sonya G; Jung, SeungWoo; Bove, Christina M; Brambilla, Paola G; Moïse, N Sydney; Stauthammer, Christopher; Quintavalla, Cecilia; Manczur, Ferenc; Stepien, Rebecca L; Mooney, Carmel; Hung, Yong-Wei; Lobetti, Remo; Tamborini, Alice.
Afiliación
  • Fox PR; Animal Medical Center, New York, New York, U.S.A.
  • Keene BW; College of Veterinary Medicine, North Carolina State University, Department of Clinical Sciences, Raleigh, North Carolina, U.S.A.
  • Lamb K; Lamb Consulting, Minneapolis, Minnesota, U.S.A.
  • Schober KE; Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, U.S.A.
  • Chetboul V; Alfort Cardiology Unit, École Nationale Vétérinaire d'Alfort, Maisons-Alfort Cedex, France.
  • Luis Fuentes V; Department of Veterinary Clinical Sciences and Services, Royal Veterinary College, Hatfield, United Kingdom.
  • Payne JR; Highcroft Veterinary Referrals, Bristol, United Kingdom.
  • Wess G; Clinic of Small Animal Medicine, Ludwig-Maximillians University, Munich, Germany.
  • Hogan DF; Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana, U.S.A.
  • Abbott JA; Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia, U.S.A.
  • Häggström J; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Culshaw G; Division of Veterinary Clinical Sciences, R(D)SVS Hospital for Small Animals Easter Bush Veterinary Centre, The University of Edinburgh, Midlothian, United Kingdom.
  • Fine-Ferreira D; Ali'i Veterinary Hospital, Kailua-Kona, Hawaii, U.S.A.
  • Cote E; Atlantic Veterinary College, Univertisy of PEI-Department of Companion Animals, Charlottetown, Prince Edward Island, Canada.
  • Trehiou-Sechi E; École Nationale Vétérinaire d'Alfort, Cardiology Unit of Alfort-Université Paris-Est, Maisons-Alfort, France.
  • Motsinger-Reif AA; Department of Statistics, North Carolina State University, Raleigh, North Carolina, U.S.A.
  • Nakamura RK; Advanced Veterinary Care Center-Cardiology, Lawndale, California, U.S.A.
  • Singh M; Veterinary Cardiac Referrals-Cardiology, Sydney, New South Wales, Australia.
  • Ware WA; Department of Veterinary Clinical Sciences, Iowa State University, Ames, Iowa, U.S.A.
  • Riesen SC; Kardiovet, Burgdorf, Switzerland.
  • Borgarelli M; Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia, U.S.A.
  • Rush JE; Department of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, U.S.A.
  • Vollmar A; Small Animal Clinic, Wissen and Bonn, Germany.
  • Lesser MB; Advanced Veterinary Care Center, Lawndale, California, U.S.A.
  • Van Israel N; Animal CardioPulmonary Consultancy, Masta, Belgium.
  • Lee PM; Department of Veterinary Clinical Sciences, Washington State University, Pullman, Washington, U.S.A.
  • Bulmer B; Tufts Veterinary Emergency Treatment & Specialties, Walpole, Massachusetts, U.S.A.
  • Santilli R; Department of Cardiology, Clinica Veterinaria Malpensa, Varese, Italy.
  • Bossbaly MJ; Veterinary Specialty & Emergency Center, Levittown, Pennsylvania, U.S.A.
  • Quick N; Ludwig-Maximilians-University Munich, Clinic of Small Animal Medicine, Munich, Germany.
  • Bussadori C; Department of Cardiology, Clinica Veterinaria Gran Sasso, Milano, Italy.
  • Bright J; Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, U.S.A.
  • Estrada AH; Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida, U.S.A.
  • Ohad DG; The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.
  • Del Palacio MJF; Departmento de Medicina y Cirugía Animal, Universidad de Murcia, Murcia, Spain.
  • Brayley JL; Veterinary Medical Specialists of Houston, Houston, Texas, U.S.A.
  • Schwartz DS; School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Gordon SG; Department of Small Animal Clinical Sciences, Texas A&M University, College Station, Texas, U.S.A.
  • Jung S; Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, Alabama, U.S.A.
  • Bove CM; Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, U.S.A.
  • Brambilla PG; Department of Veterinary Medicine, University of Milan, Milan, Italy.
  • Moïse NS; Department of Clinical Sciences, Cornell University, Ithaca, New York, U.S.A.
  • Stauthammer C; Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, Minnesota, U.S.A.
  • Quintavalla C; Department of Veterinary Sciences, University of Parma, Parma, Italy.
  • Manczur F; Department of Internal Medicine, University of Veterinary Medicine, Budapest, Hungary.
  • Stepien RL; Department of Medical Sciences, University of Wisconsin Madison School of Veterinary Medicine, Madison, Wisconsin, U.S.A.
  • Mooney C; University College Dublin Veterinary Hospital, University College Dublin, Dublin, Ireland.
  • Hung YW; Cardiospecial Veterinary Hospital, Taipei, Taiwan.
  • Lobetti R; Bryanston Veterinary Hospital, Bryanston, South Africa.
  • Tamborini A; Department of Small Animal Medicine, University College Veterinary Hospital, University College Dublin, Dublin, Ireland.
J Vet Intern Med ; 33(6): 2572-2586, 2019 Nov.
Article en En | MEDLINE | ID: mdl-31605422
BACKGROUND: Epidemiologic knowledge regarding noncardiovascular and all-cause mortality in apparently healthy cats (AH) and cats with preclinical hypertrophic cardiomyopathy (pHCM) is limited, hindering development of evidence-based healthcare guidelines. OBJECTIVES: To characterize/compare incidence rates, risk, and survival associated with noncardiovascular and all-cause mortality in AH and pHCM cats. ANIMALS: A total of 1730 client-owned cats (722 AH, 1008 pHCM) from 21 countries. METHODS: Retrospective, multicenter, longitudinal, cohort study. Long-term health data were extracted by medical record review and owner/referring veterinarian interviews. RESULTS: Noncardiovascular death occurred in 534 (30.9%) of 1730 cats observed up to 15.2 years. Proportion of noncardiovascular death did not differ significantly between cats that at study enrollment were AH or had pHCM (P = .48). Cancer, chronic kidney disease, and conditions characterized by chronic weight-loss-vomiting-diarrhea-anorexia were the most frequently recorded noncardiovascular causes of death. Incidence rates/risk of noncardiac death increased with age in AH and pHCM. All-cause death proportions were greater in pHCM than AH (65% versus 40%, respectively; P < .001) because of higher cardiovascular mortality in pHCM cats. Comparing AH with pHCM, median survival (study entry to noncardiovascular death) did not differ (AH, 9.8 years; pHCM, 8.6 years; P = .10), but all-cause survival was significantly shorter in pHCM (P = .0001). CONCLUSIONS AND CLINICAL IMPORTANCE: All-cause mortality was significantly greater in pHCM cats due to disease burden contributed by increased cardiovascular death superimposed upon noncardiovascular death.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cardiomiopatía Hipertrófica / Enfermedades de los Gatos Tipo de estudio: Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Límite: Animals Idioma: En Revista: J Vet Intern Med Asunto de la revista: MEDICINA INTERNA / MEDICINA VETERINARIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cardiomiopatía Hipertrófica / Enfermedades de los Gatos Tipo de estudio: Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Límite: Animals Idioma: En Revista: J Vet Intern Med Asunto de la revista: MEDICINA INTERNA / MEDICINA VETERINARIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos