Your browser doesn't support javascript.
loading
Peripheral tryptophan, serotonin, kynurenine, and their metabolites in major depression: A case-control study.
Colle, Romain; Masson, Perrine; Verstuyft, Céline; Fève, Bruno; Werner, Erwan; Boursier-Neyret, Claire; Walther, Bernard; David, Denis J; Boniface, Bruno; Falissard, Bruno; Chanson, Philippe; Corruble, Emmanuelle; Becquemont, Laurent.
Afiliación
  • Colle R; INSERM UMR-1178, CESP, Faculté de Médecine Paris-Sud, Paris-Saclay University, Le Kremlin Bicêtre, France.
  • Masson P; Service Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
  • Verstuyft C; Pharmacokinetics Center, Technologie Servier, Orléans, France.
  • Fève B; INSERM UMR-1178, CESP, Faculté de Médecine Paris-Sud, Paris-Saclay University, Le Kremlin Bicêtre, France.
  • Werner E; Service de Génétique moléculaire, Pharmacogénétique et Hormonologie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
  • Boursier-Neyret C; Service d'endocrinologie, Hôpital Saint-Antoine, Assistance Publique Hôpitaux de Paris, Paris, France.
  • Walther B; Sorbonne Université, INSERM UMR S_938, Centre de Recherche Saint-Antoine, Paris, France.
  • David DJ; Pharmacokinetics Center, Technologie Servier, Orléans, France.
  • Boniface B; Pharmacokinetics Center, Technologie Servier, Orléans, France.
  • Falissard B; Pharmacokinetics Center, Technologie Servier, Orléans, France.
  • Chanson P; INSERM UMR-1178, CESP, Faculté de Médecine Paris-Sud, Paris-Saclay University, Le Kremlin Bicêtre, France.
  • Corruble E; INSERM UMR-1178, CESP, Faculté de Médecine Paris-Sud, Paris-Saclay University, Le Kremlin Bicêtre, France.
  • Becquemont L; INSERM UMR-1178, CESP, Faculté de Médecine Paris-Sud, Paris-Saclay University, Le Kremlin Bicêtre, France.
Psychiatry Clin Neurosci ; 74(2): 112-117, 2020 Feb.
Article en En | MEDLINE | ID: mdl-31599111
AIM: Tryptophan is the sole precursor of both peripherally and centrally produced serotonin and kynurenine. In depressed patients, tryptophan, serotonin, kynurenine, and their metabolite levels remain unclear. Therefore, peripheral tryptophan and metabolites of serotonin and kynurenine were investigated extensively in 173 patients suffering from a current major depressive episode (MDE) and compared to 214 healthy controls (HC). METHODS: Fasting plasma levels of 11 peripheral metabolites were quantified: tryptophan, serotonin pathway (serotonin, its precursor 5-hydroxytryptophan and its metabolite 5-hydroxyindoleacetic acid), and kynurenine pathway (kynurenine and six of its metabolites: anthranilic acid, kynurenic acid, nicotinamide, picolinic acid, xanthurenic acid, and 3-hydroxyanthranilic acid). RESULTS: Sixty (34.7%) patients were antidepressant-drug free. Tryptophan levels did not differ between MDE patients and HC. Serotonin and its precursor (5-hydroxytryptophan) levels were lower in MDE patients than in HC, whereas, its metabolite (5-hydroxyindoleacetic acid) levels were within the standard range. Kynurenine and four of its metabolites (kynurenic acid, nicotinamide, picolinic acid, and xanthurenic acid) were lower in MDE patients. CONCLUSION: Whilst the results of this study demonstrate an association between the metabolites studied and depression, conclusions about causality cannot be made. This study uses the largest ever sample of MDE patients, with an extensive assessment of peripheral tryptophan metabolism in plasma. These findings provide new insights into the peripheral signature of MDE. The reasons for these changes should be further investigated. These results might suggest new antidepressant therapeutic strategies.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triptófano / Serotonina / Trastorno Depresivo Mayor / Quinurenina Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triptófano / Serotonina / Trastorno Depresivo Mayor / Quinurenina Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Australia