Protection from herpes simplex virus-induced neuropathology in mice showing delayed hypersensitivity tolerance.
J Gen Virol
; 66 ( Pt 6): 1297-303, 1985 Jun.
Article
en En
| MEDLINE
| ID: mdl-3159847
Herpes simplex virus (HSV)-susceptible mice inoculated under conditions favouring the preferential activation of T suppressor (Ts) cells acting on the delayed-type hypersensitivity (DTH) response to the virus were protected from lethal herpes encephalitis and from central nervous system (CNS) demyelination (as reflected by ear paralysis), compared to controls given normal priming. Thus, suppressed DTH was not incompatible with recovery from acute infection and may indeed have been beneficial. Protection could be transferred by T cells from donors given a 'DTH-tolerogenic' priming regime. It was unlikely that protection resulted from enhancement of other mechanisms such as cytotoxic T cell activation, antibody or interferon production, since no reduction of virus spread was observed in protected mice. In addition, several aspects of Ts cell activation by intravenous inoculation of avirulent HSV type 1 have been characterized. Suppression was virus dose-dependent and could be transferred to the efferent limb of a DTH response. Activation of Ts cells for DTH coincided with an enhanced antibody response. It is suggested that protection in this model may be mediated by Ts cells which act to limit DTH-mediated immunopathology in the CNS.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades del Sistema Nervioso Central
/
Inmunización
/
Linfocitos T Reguladores
/
Herpes Simple
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
J Gen Virol
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Reino Unido