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Synthesis of chitosan-grafted-poly(N-vinylcaprolactam) coated on the thiolated gold nanoparticles surface for controlled release of cisplatin.
Banihashem, Solmaz; Nezhati, Mahshid Nikpour; Panahi, Homayon Ahmad.
Afiliación
  • Banihashem S; Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
  • Nezhati MN; Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran. Electronic address: mah.Nikpour_Nezhati@iauctb.ac.ir.
  • Panahi HA; Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Carbohydr Polym ; 227: 115333, 2020 01 01.
Article en En | MEDLINE | ID: mdl-31590864
The gold nanoparticles surface was modified by thioglycolic acid ligand and their surface was coated by the chitosan-grafted-poly(N-vinylcaprolactam) (chitosan-g-PNVCL) copolymer. The cisplatin anticancer drug was loaded into the synthesized nanocarriers and its performance was investigated for the treatment of MCF-7 breast cancer cells in vitro. The synthesized nanoparticles were characterized using FTIR, DLS, TEM, SEM, EDX and TGA analysis. The lower critical solution temperature (LCST) of PNVCL/chitosan and PNVCL/chitosan coated gold nanoparticles were found to be 38 and 39 °C, respectively. The cisplatin loading efficiency, cisplatin release from nanoparticles at different temperatures and pH values as well as the pharmacokinetic studies were examined. The maximum cisplatin release from nanoparticles was achieved at T > LCST (42 °C) and pH of 5. The Korsemeyer-Peppas model was best described the cisplatin release from nanoparticles. The maximum MCF cell death was found to be 92% using cisplatin loaded-gold/TGA/chitosan-g-PNVCL nanoparticles under an induction heating system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Caprolactama / Cisplatino / Quitosano / Nanopartículas del Metal / Oro / Antineoplásicos Límite: Humans Idioma: En Revista: Carbohydr Polym Año: 2020 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Caprolactama / Cisplatino / Quitosano / Nanopartículas del Metal / Oro / Antineoplásicos Límite: Humans Idioma: En Revista: Carbohydr Polym Año: 2020 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido