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Enriched Gellan Gum hydrogel as visco-supplement.
Leone, Gemma; Consumi, Marco; Pepi, Simone; Pardini, Alessio; Bonechi, Claudia; Tamasi, Gabriella; Donati, Alessandro; Lamponi, Stefania; Rossi, Claudio; Magnani, Agnese.
Afiliación
  • Leone G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; INSTM, via G. Giusti 9, 50121 Firenze, Italy. Electronic address: gemma.leone@unisi.it.
  • Consumi M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; INSTM, via G. Giusti 9, 50121 Firenze, Italy.
  • Pepi S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy.
  • Pardini A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy.
  • Bonechi C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; CSGI, via della Lastruccia 3, 50019, Sesto Fiorentino, Italy.
  • Tamasi G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; CSGI, via della Lastruccia 3, 50019, Sesto Fiorentino, Italy.
  • Donati A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; CSGI, via della Lastruccia 3, 50019, Sesto Fiorentino, Italy.
  • Lamponi S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; INSTM, via G. Giusti 9, 50121 Firenze, Italy.
  • Rossi C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; CSGI, via della Lastruccia 3, 50019, Sesto Fiorentino, Italy.
  • Magnani A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, Siena 53100, Italy; INSTM, via G. Giusti 9, 50121 Firenze, Italy. Electronic address: agnese.magnani@unisi.it.
Carbohydr Polym ; 227: 115347, 2020 Jan 01.
Article en En | MEDLINE | ID: mdl-31590845
Viscosupplementation, i.e. intra-articular injection of hyaluronic acid derivatives, is considered as the most effective treatment for patients with mild to moderate osteoarthritis. Even if hyaluronic acid is still considered as the gold standard, research is now focusing on the development of new products with enhanced injectability and yet reasonable viscoelastic behavior for OA treatment. A Gellan Gum (GG) hydrogel was synthesized and coated with crosslinked polyvinyl alcohol (PVA) to protect the polysaccharide from degradation during sterilization and improve its performance for the foreseen application. Thermal analyses indicated that mixed hydrogel showed a higher degree of structuring than the bare polysaccharide core without losing its swelling properties, thanks to the hydrophylicity of both coating and cross-linking agent. The PVA coating increased elastic and viscous moduli of the polysaccharide core conferring it a higher resistance to shear and compression and better thixotropic properties. Despite the double crosslinking, hydrogel was injectable. Cytocompatibility towards chondrocytes was verified.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos Bacterianos / Alcohol Polivinílico / Hidrogeles Límite: Animals / Humans Idioma: En Revista: Carbohydr Polym Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos Bacterianos / Alcohol Polivinílico / Hidrogeles Límite: Animals / Humans Idioma: En Revista: Carbohydr Polym Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido